Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 868867..869238 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag O6117_RS04315 Protein ID WP_001317028.1
Coordinates 869044..869238 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 868867..869045 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS04285 (864619) 864619..864792 + 174 WP_001296046.1 protein YnaL -
O6117_RS04290 (864822) 864822..866195 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
O6117_RS04295 (866324) 866324..867259 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
O6117_RS04300 (867311) 867311..868546 - 1236 WP_000040852.1 site-specific integrase -
O6117_RS04305 (868548) 868548..868763 - 216 WP_000079604.1 excisionase XisR -
- (868867) 868867..869045 + 179 NuclAT_0 - Antitoxin
- (868867) 868867..869045 + 179 NuclAT_0 - Antitoxin
- (868867) 868867..869045 + 179 NuclAT_0 - Antitoxin
- (868867) 868867..869045 + 179 NuclAT_0 - Antitoxin
O6117_RS04310 (868842) 868842..869051 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
O6117_RS04315 (869044) 869044..869238 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
O6117_RS04320 (869295) 869295..870104 - 810 WP_000166319.1 recombination protein RecT -
O6117_RS04325 (870097) 870097..872697 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
O6117_RS04330 (872799) 872799..873074 - 276 WP_000632297.1 protein RacC -
O6117_RS04335 (873149) 873149..873319 - 171 WP_001352098.1 YdaE family protein -
O6117_RS04340 (873319) 873319..873540 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 867311..888985 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T267016 WP_001317028.1 NZ_CP114896:c869238-869044 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT267016 NZ_CP114896:868867-869045 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References