Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 2053637..2054008 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag O6106_RS10140 Protein ID WP_001317028.1
Coordinates 2053814..2054008 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 2053637..2053815 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS10110 (2049389) 2049389..2049562 + 174 WP_001296046.1 protein YnaL -
O6106_RS10115 (2049592) 2049592..2050965 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
O6106_RS10120 (2051094) 2051094..2052029 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
O6106_RS10125 (2052081) 2052081..2053316 - 1236 WP_000040852.1 site-specific integrase -
O6106_RS10130 (2053318) 2053318..2053533 - 216 WP_000079604.1 excisionase XisR -
- (2053637) 2053637..2053815 + 179 NuclAT_0 - Antitoxin
- (2053637) 2053637..2053815 + 179 NuclAT_0 - Antitoxin
- (2053637) 2053637..2053815 + 179 NuclAT_0 - Antitoxin
- (2053637) 2053637..2053815 + 179 NuclAT_0 - Antitoxin
O6106_RS10135 (2053612) 2053612..2053821 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
O6106_RS10140 (2053814) 2053814..2054008 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
O6106_RS10145 (2054065) 2054065..2054874 - 810 WP_000166319.1 recombination protein RecT -
O6106_RS10150 (2054867) 2054867..2057467 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
O6106_RS10155 (2057569) 2057569..2057844 - 276 WP_000632297.1 protein RacC -
O6106_RS10160 (2057919) 2057919..2058089 - 171 WP_001352098.1 YdaE family protein -
O6106_RS10165 (2058089) 2058089..2058310 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2052081..2073755 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T266997 WP_001317028.1 NZ_CP114895:c2054008-2053814 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT266997 NZ_CP114895:2053637-2053815 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References