Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) ralRA/-
Location 764866..765237 Replicon chromosome
Accession NZ_CP114894
Organism Escherichia coli strain CM19

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag O6X69_RS03840 Protein ID WP_001317028.1
Coordinates 765043..765237 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 764866..765044 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6X69_RS03810 (760618) 760618..760791 + 174 WP_001296046.1 protein YnaL -
O6X69_RS03815 (760821) 760821..762194 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
O6X69_RS03820 (762323) 762323..763258 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
O6X69_RS03825 (763310) 763310..764545 - 1236 WP_000040852.1 site-specific integrase -
O6X69_RS03830 (764547) 764547..764762 - 216 WP_000079604.1 excisionase XisR -
- (764866) 764866..765044 + 179 NuclAT_0 - Antitoxin
- (764866) 764866..765044 + 179 NuclAT_0 - Antitoxin
- (764866) 764866..765044 + 179 NuclAT_0 - Antitoxin
- (764866) 764866..765044 + 179 NuclAT_0 - Antitoxin
O6X69_RS03835 (764841) 764841..765050 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
O6X69_RS03840 (765043) 765043..765237 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
O6X69_RS03845 (765294) 765294..766103 - 810 WP_000166319.1 recombination protein RecT -
O6X69_RS03850 (766096) 766096..768696 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
O6X69_RS03855 (768798) 768798..769073 - 276 WP_000632297.1 protein RacC -
O6X69_RS03860 (769148) 769148..769318 - 171 WP_001352098.1 YdaE family protein -
O6X69_RS03865 (769318) 769318..769539 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 756051..784984 28933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-54)


Sequences


Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T266964 WP_001317028.1 NZ_CP114894:c765237-765043 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp


Antitoxin


Download         Length: 179 bp

>AT266964 NZ_CP114894:764866-765044 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7


Antitoxin

Download structure file

References