Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 631336..631707 Replicon chromosome
Accession NZ_CP114892
Organism Escherichia coli strain CM5

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag O6Q95_RS03175 Protein ID WP_001317028.1
Coordinates 631513..631707 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 631336..631514 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q95_RS03145 (627088) 627088..627261 + 174 WP_001296046.1 protein YnaL -
O6Q95_RS03150 (627291) 627291..628664 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
O6Q95_RS03155 (628793) 628793..629728 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
O6Q95_RS03160 (629780) 629780..631015 - 1236 WP_000040852.1 site-specific integrase -
O6Q95_RS03165 (631017) 631017..631232 - 216 WP_000079604.1 excisionase XisR -
- (631336) 631336..631514 + 179 NuclAT_0 - Antitoxin
- (631336) 631336..631514 + 179 NuclAT_0 - Antitoxin
- (631336) 631336..631514 + 179 NuclAT_0 - Antitoxin
- (631336) 631336..631514 + 179 NuclAT_0 - Antitoxin
O6Q95_RS03170 (631311) 631311..631520 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
O6Q95_RS03175 (631513) 631513..631707 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
O6Q95_RS03180 (631764) 631764..632573 - 810 WP_000166319.1 recombination protein RecT -
O6Q95_RS03185 (632566) 632566..635166 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
O6Q95_RS03190 (635268) 635268..635543 - 276 WP_000632297.1 protein RacC -
O6Q95_RS03195 (635618) 635618..635788 - 171 WP_001352098.1 YdaE family protein -
O6Q95_RS03200 (635788) 635788..636009 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 629780..651454 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T266915 WP_001317028.1 NZ_CP114892:c631707-631513 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT266915 NZ_CP114892:631336-631514 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References