Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1500969..1501340 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag OLR74_RS07480 Protein ID WP_001317028.1
Coordinates 1501146..1501340 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1500969..1501147 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS07450 (1496721) 1496721..1496894 + 174 WP_001296046.1 protein YnaL -
OLR74_RS07455 (1496924) 1496924..1498297 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
OLR74_RS07460 (1498426) 1498426..1499361 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
OLR74_RS07465 (1499413) 1499413..1500648 - 1236 WP_000040852.1 site-specific integrase -
OLR74_RS07470 (1500650) 1500650..1500865 - 216 WP_000079604.1 excisionase XisR -
- (1500969) 1500969..1501147 + 179 NuclAT_0 - Antitoxin
- (1500969) 1500969..1501147 + 179 NuclAT_0 - Antitoxin
- (1500969) 1500969..1501147 + 179 NuclAT_0 - Antitoxin
- (1500969) 1500969..1501147 + 179 NuclAT_0 - Antitoxin
OLR74_RS07475 (1500944) 1500944..1501153 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
OLR74_RS07480 (1501146) 1501146..1501340 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
OLR74_RS07485 (1501397) 1501397..1502206 - 810 WP_000166319.1 recombination protein RecT -
OLR74_RS07490 (1502199) 1502199..1504799 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
OLR74_RS07495 (1504901) 1504901..1505176 - 276 WP_000632297.1 protein RacC -
OLR74_RS07500 (1505251) 1505251..1505421 - 171 WP_001352098.1 YdaE family protein -
OLR74_RS07505 (1505421) 1505421..1505642 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1499413..1521087 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T262688 WP_001317028.1 NZ_CP110016:c1501340-1501146 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT262688 NZ_CP110016:1500969-1501147 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References