Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1500965..1501336 Replicon chromosome
Accession NZ_CP110014
Organism Escherichia coli strain HE_100-10

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag OLR77_RS07480 Protein ID WP_001317028.1
Coordinates 1501142..1501336 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1500965..1501143 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR77_RS07450 (1496717) 1496717..1496890 + 174 WP_001296046.1 protein YnaL -
OLR77_RS07455 (1496920) 1496920..1498293 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
OLR77_RS07460 (1498422) 1498422..1499357 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
OLR77_RS07465 (1499409) 1499409..1500644 - 1236 WP_000040852.1 site-specific integrase -
OLR77_RS07470 (1500646) 1500646..1500861 - 216 WP_000079604.1 excisionase XisR -
- (1500965) 1500965..1501143 + 179 NuclAT_0 - Antitoxin
- (1500965) 1500965..1501143 + 179 NuclAT_0 - Antitoxin
- (1500965) 1500965..1501143 + 179 NuclAT_0 - Antitoxin
- (1500965) 1500965..1501143 + 179 NuclAT_0 - Antitoxin
OLR77_RS07475 (1500940) 1500940..1501149 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
OLR77_RS07480 (1501142) 1501142..1501336 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
OLR77_RS07485 (1501393) 1501393..1502202 - 810 WP_000166319.1 recombination protein RecT -
OLR77_RS07490 (1502195) 1502195..1504795 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
OLR77_RS07495 (1504897) 1504897..1505172 - 276 WP_000632297.1 protein RacC -
OLR77_RS07500 (1505247) 1505247..1505417 - 171 WP_001352098.1 YdaE family protein -
OLR77_RS07505 (1505417) 1505417..1505638 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1499409..1521083 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T262636 WP_001317028.1 NZ_CP110014:c1501336-1501142 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT262636 NZ_CP110014:1500965-1501143 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References