254067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 2435835..2436320 Replicon chromosome
Accession NZ_CP102716
Organism Lacticaseibacillus rhamnosus strain DM065

Toxin (Protein)


Gene name yafQ Uniprot ID C2K0Y1
Locus tag NHB23_RS11280 Protein ID WP_005691636.1
Coordinates 2436135..2436320 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A508YYT1
Locus tag NHB23_RS11275 Protein ID WP_014571130.1
Coordinates 2435835..2436107 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB23_RS11250 (NHB23_011250) 2431776..2432372 - 597 WP_005691643.1 IS607 family transposase -
NHB23_RS11255 (NHB23_011255) 2432515..2433090 - 576 WP_014571131.1 DNA-3-methyladenine glycosylase I -
NHB23_RS11260 (NHB23_011260) 2433244..2434407 - 1164 WP_005691640.1 MFS transporter -
NHB23_RS11265 (NHB23_011265) 2434489..2434782 - 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
NHB23_RS11270 (NHB23_011270) 2435025..2435273 - 249 WP_005691639.1 hypothetical protein -
NHB23_RS11275 (NHB23_011275) 2435835..2436107 + 273 WP_014571130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NHB23_RS11280 (NHB23_011280) 2436135..2436320 + 186 WP_005691636.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
NHB23_RS11285 (NHB23_011285) 2436544..2437959 + 1416 WP_005691634.1 exonuclease domain-containing protein -
NHB23_RS11290 (NHB23_011290) 2438202..2439077 - 876 WP_024305787.1 XRE family transcriptional regulator -
NHB23_RS11295 (NHB23_011295) 2439524..2440132 + 609 WP_005691630.1 hypothetical protein -
NHB23_RS11300 (NHB23_011300) 2440624..2441313 - 690 WP_005691628.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2430309..2441313 11004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-57)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6781.86 Da        Isoelectric Point: 7.4698

>T254067 WP_005691636.1 NZ_CP102716:2436135-2436320 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE

Download         Length: 186 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10005.62 Da        Isoelectric Point: 9.5939

>AT254067 WP_014571130.1 NZ_CP102716:2435835-2436107 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2J6C9

Antitoxin

Source ID Structure
AlphaFold DB A0A508YYT1

References