Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1285996..1286367 Replicon chromosome
Accession NZ_CP102380
Organism Escherichia coli strain BM28

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag NR349_RS06270 Protein ID WP_001317028.1
Coordinates 1286173..1286367 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1285996..1286174 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR349_RS06245 (1281951) 1281951..1283324 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
NR349_RS06250 (1283453) 1283453..1284388 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
NR349_RS06255 (1284440) 1284440..1285675 - 1236 WP_000040852.1 site-specific integrase -
NR349_RS06260 (1285677) 1285677..1285892 - 216 WP_000079604.1 excisionase XisR -
- (1285996) 1285996..1286174 + 179 NuclAT_0 - Antitoxin
- (1285996) 1285996..1286174 + 179 NuclAT_0 - Antitoxin
- (1285996) 1285996..1286174 + 179 NuclAT_0 - Antitoxin
- (1285996) 1285996..1286174 + 179 NuclAT_0 - Antitoxin
NR349_RS06265 (1285971) 1285971..1286180 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
NR349_RS06270 (1286173) 1286173..1286367 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
NR349_RS06275 (1286424) 1286424..1287233 - 810 WP_000166319.1 recombination protein RecT -
NR349_RS06280 (1287226) 1287226..1289825 - 2600 Protein_1220 exodeoxyribonuclease VIII -
NR349_RS06285 (1289927) 1289927..1290202 - 276 WP_000632297.1 protein RacC -
NR349_RS06290 (1290277) 1290277..1290447 - 171 WP_001352098.1 YdaE family protein -
NR349_RS06295 (1290447) 1290447..1290668 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1284440..1306114 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T253570 WP_001317028.1 NZ_CP102380:c1286367-1286173 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT253570 NZ_CP102380:1285996-1286174 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References