Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1424192..1424563 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag NR351_RS07050 Protein ID WP_001317028.1
Coordinates 1424369..1424563 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1424192..1424370 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS07025 (1420147) 1420147..1421520 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
NR351_RS07030 (1421649) 1421649..1422584 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
NR351_RS07035 (1422636) 1422636..1423871 - 1236 WP_000040852.1 site-specific integrase -
NR351_RS07040 (1423873) 1423873..1424088 - 216 WP_000079604.1 excisionase XisR -
- (1424192) 1424192..1424370 + 179 NuclAT_0 - Antitoxin
- (1424192) 1424192..1424370 + 179 NuclAT_0 - Antitoxin
- (1424192) 1424192..1424370 + 179 NuclAT_0 - Antitoxin
- (1424192) 1424192..1424370 + 179 NuclAT_0 - Antitoxin
NR351_RS07045 (1424167) 1424167..1424376 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
NR351_RS07050 (1424369) 1424369..1424563 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
NR351_RS07055 (1424620) 1424620..1425429 - 810 WP_000166319.1 recombination protein RecT -
NR351_RS07060 (1425422) 1425422..1428022 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
NR351_RS07065 (1428124) 1428124..1428399 - 276 WP_000632297.1 protein RacC -
NR351_RS07070 (1428474) 1428474..1428644 - 171 WP_001352098.1 YdaE family protein -
NR351_RS07075 (1428644) 1428644..1428865 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1415377..1444310 28933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T253501 WP_001317028.1 NZ_CP102378:c1424563-1424369 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT253501 NZ_CP102378:1424192-1424370 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References