Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 73645..74066 | Replicon | plasmid unnamed |
| Accession | NZ_CP099589 | ||
| Organism | Escherichia coli strain EMG2 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | NHF38_RS23110 | Protein ID | WP_096937776.1 |
| Coordinates | 73645..73770 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 73868..74066 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NHF38_RS23075 (69042) | 69042..69731 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| NHF38_RS23080 (69918) | 69918..70301 | - | 384 | WP_001151527.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| NHF38_RS23085 (70622) | 70622..71224 | + | 603 | WP_000243701.1 | transglycosylase SLT domain-containing protein | - |
| NHF38_RS23090 (71520) | 71520..72341 | - | 822 | WP_001234417.1 | DUF932 domain-containing protein | - |
| NHF38_RS23095 (72460) | 72460..72747 | - | 288 | WP_000107542.1 | hypothetical protein | - |
| NHF38_RS23100 (72772) | 72772..72978 | - | 207 | WP_000547965.1 | hypothetical protein | - |
| NHF38_RS23105 (73048) | 73048..73344 | + | 297 | Protein_71 | hypothetical protein | - |
| NHF38_RS23110 (73645) | 73645..73770 | - | 126 | WP_096937776.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| NHF38_RS23115 (73712) | 73712..73861 | - | 150 | Protein_73 | DUF5431 family protein | - |
| - (73868) | 73868..74066 | - | 199 | NuclAT_0 | - | Antitoxin |
| - (73868) | 73868..74066 | - | 199 | NuclAT_0 | - | Antitoxin |
| - (73868) | 73868..74066 | - | 199 | NuclAT_0 | - | Antitoxin |
| - (73868) | 73868..74066 | - | 199 | NuclAT_0 | - | Antitoxin |
| NHF38_RS23120 (74035) | 74035..74797 | - | 763 | Protein_74 | plasmid SOS inhibition protein A | - |
| NHF38_RS23125 (74794) | 74794..75228 | - | 435 | WP_000845928.1 | conjugation system SOS inhibitor PsiB | - |
| NHF38_RS23130 (75283) | 75283..77241 | - | 1959 | WP_000117173.1 | ParB/RepB/Spo0J family partition protein | - |
| NHF38_RS23135 (77307) | 77307..77540 | - | 234 | WP_000005990.1 | DUF905 family protein | - |
| NHF38_RS23140 (77597) | 77597..78136 | - | 540 | WP_000290801.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Conjugative plasmid | - | - | 1..99158 | 99158 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4806.72 Da Isoelectric Point: 8.4890
>T249159 WP_096937776.1 NZ_CP099589:c73770-73645 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK
Download Length: 126 bp
Antitoxin
Download Length: 199 bp
>AT249159 NZ_CP099589:c74066-73868 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
