Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1933306..1933918 Replicon chromosome
Accession NC_013971
Organism Erwinia amylovora ATCC 49946

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag EAM_RS08665 Protein ID WP_012906750.1
Coordinates 1933306..1933485 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag EAM_RS08670 Protein ID WP_004157632.1
Coordinates 1933508..1933918 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAM_RS08645 (EAM_1781) 1928864..1929814 + 951 WP_004157624.1 DUF1471 family protein YdgH -
EAM_RS08650 (EAM_1782) 1930022..1931413 + 1392 WP_004157625.1 amino acid permease -
EAM_RS08655 (EAM_1783) 1931417..1931881 - 465 WP_004157626.1 hypothetical protein -
EAM_RS08660 (EAM_1784) 1932058..1932786 + 729 WP_004157629.1 two-component system response regulator RstA -
EAM_RS08665 (EAM_1786) 1933306..1933485 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
EAM_RS08670 (EAM_1787) 1933508..1933918 + 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EAM_RS08675 (EAM_1788) 1933974..1934975 + 1002 WP_004157633.1 acyltransferase -
EAM_RS18310 (EAM_1791) 1935846..1936058 - 213 WP_004157635.1 hypothetical protein -
EAM_RS19620 (EAM_1793) 1936316..1936489 - 174 WP_004157636.1 hypothetical protein -
EAM_RS19405 (EAM_1794) 1936584..1936757 - 174 WP_013036045.1 hypothetical protein -
EAM_RS08680 (EAM_1795) 1936768..1937040 - 273 WP_004157637.1 hypothetical protein -
EAM_RS08685 (EAM_1798) 1937670..1938260 + 591 WP_223386180.1 DapH/DapD/GlmU-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1927144..1940574 13430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T24689 WP_012906750.1 NC_013971:1933306-1933485 [Erwinia amylovora ATCC 49946]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T24689 NC_013971:1933306-1933485 [Erwinia amylovora ATCC 49946]
ATGGATAGCAGGAATGCAATAGCAATGATAGAGGCCGATGGATGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATCCCCAAAAGGACATACCGCTACCAACGCTGAAAAGCATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT24689 WP_004157632.1 NC_013971:1933508-1933918 [Erwinia amylovora ATCC 49946]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT24689 NC_013971:1933508-1933918 [Erwinia amylovora ATCC 49946]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References