Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 572687..573299 Replicon chromosome
Accession NZ_CP076591
Organism Erwinia amylovora isolate CP201142

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag KQH37_RS02550 Protein ID WP_012906750.1
Coordinates 573120..573299 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag KQH37_RS02545 Protein ID WP_004157632.1
Coordinates 572687..573097 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH37_RS02510 (KQH37_02540) 568345..568935 - 591 WP_223386180.1 DapH/DapD/GlmU-related protein -
KQH37_RS02515 (KQH37_02545) 569565..569837 + 273 WP_004157637.1 hypothetical protein -
KQH37_RS02520 (KQH37_02550) 569848..570021 + 174 WP_013036045.1 hypothetical protein -
KQH37_RS02525 (KQH37_02555) 570116..570289 + 174 WP_004157636.1 hypothetical protein -
KQH37_RS02530 (KQH37_02560) 570547..570759 + 213 WP_004157635.1 hypothetical protein -
KQH37_RS02535 (KQH37_02565) 571050..571223 - 174 WP_180269018.1 hypothetical protein -
KQH37_RS02540 (KQH37_02570) 571630..572631 - 1002 WP_004157633.1 acyltransferase -
KQH37_RS02545 (KQH37_02575) 572687..573097 - 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KQH37_RS02550 (KQH37_02580) 573120..573299 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
KQH37_RS02555 (KQH37_02585) 573819..574547 - 729 WP_004157629.1 two-component system response regulator RstA -
KQH37_RS02560 (KQH37_02590) 574724..575188 + 465 WP_004157626.1 hypothetical protein -
KQH37_RS02565 (KQH37_02595) 575192..576583 - 1392 WP_004157625.1 amino acid permease -
KQH37_RS02570 (KQH37_02600) 576791..577741 - 951 WP_004157624.1 DUF1471 family protein YdgH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 566031..582145 16114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T205982 WP_012906750.1 NZ_CP076591:c573299-573120 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T205982 NZ_CP101987:c4078397-4078014 [Cellulomonas xiejunii]
GTGAGGCTGGTCCTCGACACGAACGTCCTGATCGACGGTCTGGTGCCGACCGGCACCGGCGATGAAGCCGCGATCAGCAT
GGCGACGCTGGCCGAGCTGCGCTTCGGCGTCCTGATCGCGCGCACCGCCGAGAGCAGGTCGGCGCGGATGCGGGTGCTGT
CGAGCGCCGAGAGCGCGCTGGCAGCCCTCCCGATCGACGACGCGGTCGCGTCTTCCTACGCCCTGCTCGCGACGAAGACG
GTGGCGGCCGGGCGACAGCCGCGCGCCCGAGCGTTCGACCTGCTGATCGCGGCGACCGCCCACGCACATGGCGCCGCGCT
CGTGACGAGGAACATCGACGACTTCACGGGTCTCGACGACGTCCTCGACGTCCGCTTGCCGTAG

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT205982 WP_004157632.1 NZ_CP076591:c573097-572687 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT205982 NZ_CP101987:c4078657-4078394 [Cellulomonas xiejunii]
ATGACGACCGTCGGGGTGCGCGAGCTCAGGCAGGACGCGTCCGGTGTCCTGCGCCTCGTCGAGGCGGGCGAGCGAGTCGT
CGTGACGGTTCACGGGCGGCCCGTCGCCGACCTGGTGCCGCACTCCGAGGCCCGTCCTACGTGGCGCCCGGTCGCGGACC
TGGCGGCACTGTTCCGCGGCGTGGACGACCCGGACTGGGAGCAGGACATGGCGCTGGTCGACGGTGCCGCGACCGACCCG
TTCGAGCGAGGCTCCGACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References