152394

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1872895..1873507 Replicon chromosome
Accession NZ_CP050240
Organism Erwinia amylovora strain FB-20

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag EGZ89_RS08320 Protein ID WP_012906750.1
Coordinates 1873328..1873507 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag EGZ89_RS08315 Protein ID WP_004157632.1
Coordinates 1872895..1873305 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGZ89_RS08285 1868553..1869167 - 615 WP_004166850.1 acetyltransferase -
EGZ89_RS08290 1869773..1870045 + 273 WP_004157637.1 hypothetical protein -
EGZ89_RS08295 1870056..1870229 + 174 WP_013036045.1 hypothetical protein -
EGZ89_RS08300 1870324..1870497 + 174 WP_004157636.1 hypothetical protein -
EGZ89_RS08305 1870755..1870967 + 213 WP_004157635.1 hypothetical protein -
EGZ89_RS08310 1871838..1872839 - 1002 WP_004157633.1 acyltransferase -
EGZ89_RS08315 1872895..1873305 - 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGZ89_RS08320 1873328..1873507 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
EGZ89_RS08325 1874027..1874755 - 729 WP_004157629.1 two-component system response regulator RstA -
EGZ89_RS08330 1874932..1875396 + 465 WP_004157626.1 hypothetical protein -
EGZ89_RS08335 1875400..1876791 - 1392 WP_004157625.1 amino acid permease -
EGZ89_RS08340 1876999..1877949 - 951 WP_004157624.1 DUF1471 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1866239..1882353 16114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T152394 WP_012906750.1 NZ_CP050240:c1873507-1873328 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T152394 NZ_CP066143:5043565-5043849 [Klebsiella pneumoniae U-0608239]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT152394 WP_004157632.1 NZ_CP050240:c1873305-1872895 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT152394 NZ_CP066143:5043333-5043575 [Klebsiella pneumoniae U-0608239]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References