Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 193135..193747 Replicon chromosome
Accession NZ_CP076595
Organism Erwinia amylovora isolate CP20130202

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag KQH34_RS00925 Protein ID WP_012906750.1
Coordinates 193568..193747 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag KQH34_RS00920 Protein ID WP_004157632.1
Coordinates 193135..193545 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH34_RS00890 (KQH34_00895) 188793..189407 - 615 WP_004166850.1 DapH/DapD/GlmU-related protein -
KQH34_RS00895 (KQH34_00900) 190013..190285 + 273 WP_004157637.1 hypothetical protein -
KQH34_RS00900 (KQH34_00905) 190296..190469 + 174 WP_013036045.1 hypothetical protein -
KQH34_RS00905 (KQH34_00910) 190564..190737 + 174 WP_004157636.1 hypothetical protein -
KQH34_RS00910 (KQH34_00915) 190995..191207 + 213 WP_004157635.1 hypothetical protein -
KQH34_RS00915 (KQH34_00920) 192078..193079 - 1002 WP_004157633.1 acyltransferase -
KQH34_RS00920 (KQH34_00925) 193135..193545 - 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KQH34_RS00925 (KQH34_00930) 193568..193747 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
KQH34_RS00930 (KQH34_00935) 194267..194995 - 729 WP_004157629.1 two-component system response regulator RstA -
KQH34_RS00935 (KQH34_00940) 195172..195636 + 465 WP_004157626.1 hypothetical protein -
KQH34_RS00940 (KQH34_00945) 195640..197031 - 1392 WP_004157625.1 amino acid permease -
KQH34_RS00945 (KQH34_00950) 197239..198189 - 951 WP_004157624.1 DUF1471 family protein YdgH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 186479..202593 16114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T206012 WP_012906750.1 NZ_CP076595:c193747-193568 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T206012 NZ_CP102065:c2555202-2555101 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT206012 WP_004157632.1 NZ_CP076595:c193545-193135 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT206012 NZ_CP102065:2554978-2555156 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References