Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1673158..1673770 Replicon chromosome
Accession NZ_CP076590
Organism Erwinia amylovora isolate CP200930

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag KQH39_RS07855 Protein ID WP_012906750.1
Coordinates 1673158..1673337 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag KQH39_RS07860 Protein ID WP_004157632.1
Coordinates 1673360..1673770 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH39_RS07835 (KQH39_07830) 1668716..1669666 + 951 WP_004157624.1 DUF1471 family protein YdgH -
KQH39_RS07840 (KQH39_07835) 1669874..1671265 + 1392 WP_004157625.1 amino acid permease -
KQH39_RS07845 (KQH39_07840) 1671269..1671733 - 465 WP_004157626.1 hypothetical protein -
KQH39_RS07850 (KQH39_07845) 1671910..1672638 + 729 WP_004157629.1 two-component system response regulator RstA -
KQH39_RS07855 (KQH39_07850) 1673158..1673337 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
KQH39_RS07860 (KQH39_07855) 1673360..1673770 + 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KQH39_RS07865 (KQH39_07860) 1673826..1674827 + 1002 WP_004157633.1 acyltransferase -
KQH39_RS07870 (KQH39_07865) 1675698..1675910 - 213 WP_004157635.1 hypothetical protein -
KQH39_RS07875 (KQH39_07870) 1676168..1676341 - 174 WP_004157636.1 hypothetical protein -
KQH39_RS07880 (KQH39_07875) 1676436..1676609 - 174 WP_013036045.1 hypothetical protein -
KQH39_RS07885 (KQH39_07880) 1676620..1676892 - 273 WP_004157637.1 hypothetical protein -
KQH39_RS07890 (KQH39_07885) 1677522..1678112 + 591 WP_223386180.1 DapH/DapD/GlmU-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1666996..1680426 13430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T205977 WP_012906750.1 NZ_CP076590:1673158-1673337 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T205977 NZ_CP101985:1471966-1472220 [Streptococcus mutans]
ATGTTTAATTTTACCGAACAGGCTTGGCAAGACTACATTTCTTGGCAACAAGAGGATAAGAAAACGCTCAAGCGTATCAA
TCGTTTAATTGAGGATATTAAACGAAACCCTTTTGATGGTATTGGAAAGCCCGAACCGTTGAAATATCGCTATTCTGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGTTTAGTCTATATGATAGAAGAAAGCGAGATTTATTTTTTATCCTTCCGA
GATCATTATAAATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT205977 WP_004157632.1 NZ_CP076590:1673360-1673770 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT205977 NZ_CP101985:1471707-1471973 [Streptococcus mutans]
ATGGAAGCTGTGGTTTATTCAAACTTTAGAAATAATCTAAAAGACTATATGAAGAAGGTCAATGATGAATACGAGCCTTT
GATGGTGGTTAATAAGAATCCTGACGAAGATATTGTTGTCTTATCTAAGGAAAATTGGGATAGTATTCAAGAAACCATTC
GTTTAATGAACAATGAATATCTTTCTGACAAAGTTCTATCAGGCATAGAACAAGTCAAACAAAGGAAAATAACCAAGCAT
GCCTTATTAGAGGTGAAGGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References