23778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 933559..934118 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VCD_RS18730 Protein ID WP_000578476.1
Coordinates 933840..934118 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VCD_RS18725 Protein ID WP_000381183.1
Coordinates 933559..933843 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS18715 932253..932666 - 414 WP_000049423.1 VOC family protein -
VCD_RS18720 932850..933365 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
VCD_RS18725 933559..933843 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VCD_RS18730 933840..934118 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VCD_RS18735 934257..934652 - 396 WP_001000867.1 hypothetical protein -
VCD_RS20685 934903..935028 - 126 WP_001905700.1 DUF645 family protein -
VCD_RS18745 935327..935848 - 522 WP_000921691.1 DUF2442 domain-containing protein -
VCD_RS18750 935842..936111 - 270 WP_001114075.1 DUF4160 domain-containing protein -
VCD_RS20880 936142..936246 - 105 WP_099607150.1 acetyltransferase -
VCD_RS18755 936303..936902 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
VCD_RS18760 937052..937924 - 873 WP_000254716.1 DUF3800 domain-containing protein -
VCD_RS18765 938099..938317 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
VCD_RS18770 938381..938818 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 931766..938266 6500
- inside Genomic island catB9 - 932253..1057432 125179
flank IS/Tn - - 938381..938818 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T23778 WP_000578476.1 NC_012667:933840-934118 [Vibrio cholerae MJ-1236]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T23778 NC_012667:933840-934118 [Vibrio cholerae MJ-1236]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT23778 WP_000381183.1 NC_012667:933559-933843 [Vibrio cholerae MJ-1236]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT23778 NC_012667:933559-933843 [Vibrio cholerae MJ-1236]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References