Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 933559..934118 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VCD_RS18730 Protein ID WP_000578476.1
Coordinates 933840..934118 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VCD_RS18725 Protein ID WP_000381183.1
Coordinates 933559..933843 (+) Length 95 a.a.

Genomic Context

VCD_RS18725VCD_RS18730VCD_RS18715VCD_RS18720VCD_RS18735VCD_RS20685VCD_RS18745VCD_RS18750VCD_RS20880VCD_RS18755VCD_RS18760VCD_RS18765VCD_RS18770
Location: 933559..933843 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 933840..934118 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 932253..932666 (414 bp)
Type: Others
Protein ID: WP_000049423.1
Location: 932850..933365 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 934257..934652 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 934903..935028 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 935327..935848 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 935842..936111 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 936142..936246 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 936303..936902 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 937052..937924 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 938099..938317 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 938381..938818 (438 bp)
Type: Others
Protein ID: WP_000503169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS18715932253..932666-414WP_000049423.1VOC family protein-
VCD_RS18720932850..933365-516WP_000343779.1GNAT family N-acetyltransferase-
VCD_RS18725933559..933843+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VCD_RS18730933840..934118+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VCD_RS18735934257..934652-396WP_001000867.1hypothetical protein-
VCD_RS20685934903..935028-126WP_001905700.1DUF645 family protein-
VCD_RS18745935327..935848-522WP_000921691.1DUF2442 domain-containing protein-
VCD_RS18750935842..936111-270WP_001114075.1DUF4160 domain-containing protein-
VCD_RS20880936142..936246-105WP_099607150.1acetyltransferase-
VCD_RS18755936303..936902-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VCD_RS18760937052..937924-873WP_000254716.1DUF3800 domain-containing protein-
VCD_RS18765938099..938317-219WP_071908318.1GNAT family N-acetyltransferase-
VCD_RS18770938381..938818-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron--931766..9382666500
-insideGenomic islandcatB9-932253..1057432125179
flankIS/Tn--938381..938818437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T23778 WP_000578476.1 NC_012667:933840-934118 [Vibrio cholerae MJ-1236]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T23778 NC_012667:933840-934118 [Vibrio cholerae MJ-1236]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT23778 WP_000381183.1 NC_012667:933559-933843 [Vibrio cholerae MJ-1236]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT23778 NC_012667:933559-933843 [Vibrio cholerae MJ-1236]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References