Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 461732..462291 Replicon chromosome II
Accession NC_012583
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VC395_RS16710 Protein ID WP_000578476.1
Coordinates 461732..462010 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VC395_RS16715 Protein ID WP_000381183.1
Coordinates 462007..462291 (-) Length 95 a.a.

Genomic Context

VC395_RS16665VC395_RS16670VC395_RS16675VC395_RS16680VC395_RS20935VC395_RS16685VC395_RS16690VC395_RS20685VC395_RS16705VC395_RS16720VC395_RS16725VC395_RS16735VC395_RS16710VC395_RS16715VC395_RS16740VC395_RS16745VC395_RS16750
Location: 457032..457469 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 457533..457751 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 457926..458798 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 458948..459547 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 459604..459708 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 459739..460008 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 460002..460523 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 460822..460947 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 461198..461593 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 462485..463000 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 463184..463597 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 464152..465329 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 461732..462010 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 462007..462291 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 465409..465678 (270 bp)
Type: Others
Protein ID: WP_000402869.1
Location: 465692..466636 (945 bp)
Type: Others
Protein ID: WP_001027829.1
Location: 466753..467160 (408 bp)
Type: Others
Protein ID: WP_000022491.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VC395_RS16665457032..457469+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
VC395_RS16670457533..457751+219WP_071908318.1GNAT family N-acetyltransferase-
VC395_RS16675457926..458798+873WP_000254716.1DUF3800 domain-containing protein-
VC395_RS16680458948..459547+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VC395_RS20935459604..459708+105WP_099607150.1acetyltransferase-
VC395_RS16685459739..460008+270WP_001114075.1DUF4160 domain-containing protein-
VC395_RS16690460002..460523+522WP_000921691.1DUF2442 domain-containing protein-
VC395_RS20685460822..460947+126WP_001905700.1DUF645 family protein-
VC395_RS16705461198..461593+396WP_001000867.1hypothetical protein-
VC395_RS16710461732..462010-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VC395_RS16715462007..462291-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VC395_RS16720462485..463000+516WP_000343779.1GNAT family N-acetyltransferase-
VC395_RS16725463184..463597+414WP_000049420.1VOC family protein-
VC395_RS16735464152..465329+1178WP_086010879.1IS3-like element ISVch4 family transposase-
VC395_RS16740465409..465678-270WP_000402869.1hypothetical protein-
VC395_RS16745465692..466636-945WP_001027829.1hypothetical protein-
VC395_RS16750466753..467160-408WP_000022491.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--427343..47117843835
-insideIntegron--450510..46408413574
flankIS/Tn--457032..457469437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T23740 WP_000578476.1 NC_012583:c462010-461732 [Vibrio cholerae O395]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T23740 NC_012583:c462010-461732 [Vibrio cholerae O395]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT23740 WP_000381183.1 NC_012583:c462291-462007 [Vibrio cholerae O395]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT23740 NC_012583:c462291-462007 [Vibrio cholerae O395]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References