Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 459604..460008 Replicon chromosome II
Accession NC_012583
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag VC395_RS16685 Protein ID WP_001114075.1
Coordinates 459739..460008 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag VC395_RS20935 Protein ID WP_099607150.1
Coordinates 459604..459708 (+) Length 35 a.a.

Genomic Context

VC395_RS16645VC395_RS16650VC395_RS16655VC395_RS16660VC395_RS16665VC395_RS16670VC395_RS16675VC395_RS16680VC395_RS20935VC395_RS16685VC395_RS16690VC395_RS20685VC395_RS16705VC395_RS16720VC395_RS16725VC395_RS16710VC395_RS16715
Location: 454637..455554 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 455762..456004 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 456179..456568 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 456704..456913 (210 bp)
Type: Others
Protein ID: Protein_484
Location: 457032..457469 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 457533..457751 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 457926..458798 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 458948..459547 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 459604..459708 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 459739..460008 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 460002..460523 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 460822..460947 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 461198..461593 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 462485..463000 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 463184..463597 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 461732..462010 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 462007..462291 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VC395_RS16645454637..455554+918WP_000186333.1alpha/beta hydrolase-
VC395_RS16650455762..456004+243WP_000107462.1hypothetical protein-
VC395_RS16655456179..456568+390WP_001081302.1hypothetical protein-
VC395_RS16660456704..456913+210Protein_484GNAT family N-acetyltransferase-
VC395_RS16665457032..457469+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
VC395_RS16670457533..457751+219WP_071908318.1GNAT family N-acetyltransferase-
VC395_RS16675457926..458798+873WP_000254716.1DUF3800 domain-containing protein-
VC395_RS16680458948..459547+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VC395_RS20935459604..459708+105WP_099607150.1acetyltransferaseAntitoxin
VC395_RS16685459739..460008+270WP_001114075.1DUF4160 domain-containing proteinToxin
VC395_RS16690460002..460523+522WP_000921691.1DUF2442 domain-containing protein-
VC395_RS20685460822..460947+126WP_001905700.1DUF645 family protein-
VC395_RS16705461198..461593+396WP_001000867.1hypothetical protein-
VC395_RS16710461732..462010-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
VC395_RS16715462007..462291-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
VC395_RS16720462485..463000+516WP_000343779.1GNAT family N-acetyltransferase-
VC395_RS16725463184..463597+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--427343..47117843835
-insideIntegron--450510..46408413574
flankIS/Tn--457032..457469437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T23738 WP_001114075.1 NC_012583:459739-460008 [Vibrio cholerae O395]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T23738 NC_012583:459739-460008 [Vibrio cholerae O395]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT23738 WP_099607150.1 NC_012583:459604-459708 [Vibrio cholerae O395]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT23738 NC_012583:459604-459708 [Vibrio cholerae O395]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References