23737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 453856..454403 Replicon chromosome II
Accession NC_012583
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag VC395_RS16640 Protein ID WP_000229317.1
Coordinates 454101..454403 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag VC395_RS16635 Protein ID WP_000861987.1
Coordinates 453856..454113 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC395_RS16595 449225..449719 - 495 WP_000477435.1 hypothetical protein -
VC395_RS16600 450016..450513 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
VC395_RS16605 450510..450782 - 273 WP_000246253.1 DUF1778 domain-containing protein -
VC395_RS16610 451013..451681 + 669 WP_000043871.1 hypothetical protein -
VC395_RS16615 451833..452120 + 288 WP_000426470.1 hypothetical protein -
VC395_RS16620 452261..452632 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
VC395_RS21085 452699..453124 + 426 WP_001882332.1 DUF1778 domain-containing protein -
VC395_RS16630 453121..453654 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
VC395_RS16635 453856..454113 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VC395_RS16640 454101..454403 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VC395_RS16645 454637..455554 + 918 WP_000186333.1 alpha/beta hydrolase -
VC395_RS16650 455762..456004 + 243 WP_000107462.1 hypothetical protein -
VC395_RS16655 456179..456568 + 390 WP_001081302.1 hypothetical protein -
VC395_RS16660 456704..456913 + 210 Protein_484 GNAT family N-acetyltransferase -
VC395_RS16665 457032..457469 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
VC395_RS16670 457533..457751 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
VC395_RS16675 457926..458798 + 873 WP_000254716.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 427343..471178 43835
- inside Integron - - 450510..464084 13574
flank IS/Tn - - 457032..457469 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T23737 WP_000229317.1 NC_012583:454101-454403 [Vibrio cholerae O395]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T23737 NC_012583:454101-454403 [Vibrio cholerae O395]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT23737 WP_000861987.1 NC_012583:453856-454113 [Vibrio cholerae O395]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT23737 NC_012583:453856-454113 [Vibrio cholerae O395]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References