23734

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 429251..429779 Replicon chromosome II
Accession NC_012583
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag VC395_RS16465 Protein ID WP_000221354.1
Coordinates 429492..429779 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag VC395_RS16460 Protein ID WP_001250179.1
Coordinates 429251..429502 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC395_RS16420 424519..424833 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
VC395_RS16425 424970..425404 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
VC395_RS21070 425572..425727 + 156 WP_000751734.1 hypothetical protein -
VC395_RS16435 425852..426832 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
VC395_RS16440 426900..427172 + 273 Protein_439 CatB-related O-acetyltransferase -
VC395_RS16445 427343..428035 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
VC395_RS16450 428035..428436 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
VC395_RS20655 428406..428549 + 144 WP_071908341.1 DUF3265 domain-containing protein -
VC395_RS16455 428624..429037 + 414 WP_000049417.1 VOC family protein -
VC395_RS16460 429251..429502 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VC395_RS16465 429492..429779 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VC395_RS16470 429907..430362 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
VC395_RS16475 430684..430836 + 153 WP_001884520.1 DUF645 family protein -
VC395_RS16480 431092..431337 - 246 WP_001912198.1 hypothetical protein -
VC395_RS16485 431550..433298 - 1749 WP_000063386.1 hypothetical protein -
VC395_RS16490 433295..433630 - 336 WP_000978438.1 hypothetical protein -
VC395_RS16495 433934..434278 - 345 WP_001912196.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 344619..430484 85865
flank IS/Tn - - 425852..426832 980
- inside Prophage - - 427343..471178 43835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T23734 WP_000221354.1 NC_012583:429492-429779 [Vibrio cholerae O395]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T23734 NC_012583:429492-429779 [Vibrio cholerae O395]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCCCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT23734 WP_001250179.1 NC_012583:429251-429502 [Vibrio cholerae O395]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT23734 NC_012583:429251-429502 [Vibrio cholerae O395]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References