Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 427343..428436 Replicon chromosome II
Accession NC_012583
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag VC395_RS16450 Protein ID WP_000351248.1
Coordinates 428035..428436 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag VC395_RS16445 Protein ID WP_001047169.1
Coordinates 427343..428035 (+) Length 231 a.a.

Genomic Context

VC395_RS16400VC395_RS21115VC395_RS20375VC395_RS16405VC395_RS16415VC395_RS16420VC395_RS16425VC395_RS21070VC395_RS16440VC395_RS16445VC395_RS16450VC395_RS20655VC395_RS16455VC395_RS16460VC395_RS16465VC395_RS16470VC395_RS16475VC395_RS16435VC395_RS16480VC395_RS16485
Location: 422694..422963 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 423281..423452 (172 bp)
Type: Others
Protein ID: Protein_431
Location: 423569..423683 (115 bp)
Type: Others
Protein ID: Protein_432
Location: 423632..423859 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 424200..424532 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 424519..424833 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 424970..425404 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 425572..425727 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 426900..427172 (273 bp)
Type: Others
Protein ID: Protein_439
Location: 427343..428035 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 428035..428436 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 428406..428549 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 428624..429037 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 429251..429502 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 429492..429779 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 429907..430362 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 430684..430836 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 425852..426832 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 431092..431337 (246 bp)
Type: Others
Protein ID: WP_001912198.1
Location: 431550..433298 (1749 bp)
Type: Others
Protein ID: WP_000063386.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VC395_RS16400422694..422963+270WP_001198131.1hypothetical protein-
VC395_RS21115423281..423452+172Protein_431DUF645 family protein-
VC395_RS20375423569..423683+115Protein_432acetyltransferase-
VC395_RS16405423632..423859+228WP_001894457.1DUF1289 domain-containing protein-
VC395_RS16415424200..424532+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
VC395_RS16420424519..424833+315WP_000071008.1DNA-binding transcriptional regulator-
VC395_RS16425424970..425404+435WP_000256036.1GNAT family N-acetyltransferase-
VC395_RS21070425572..425727+156WP_000751734.1hypothetical protein-
VC395_RS16435425852..426832-981WP_000019370.1IS5-like element ISVch5 family transposase-
VC395_RS16440426900..427172+273Protein_439CatB-related O-acetyltransferase-
VC395_RS16445427343..428035+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
VC395_RS16450428035..428436+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
VC395_RS20655428406..428549+144WP_071908341.1DUF3265 domain-containing protein-
VC395_RS16455428624..429037+414WP_000049417.1VOC family protein-
VC395_RS16460429251..429502+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VC395_RS16465429492..429779+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
VC395_RS16470429907..430362+456WP_001245327.1GNAT family N-acetyltransferase-
VC395_RS16475430684..430836+153WP_001884520.1DUF645 family protein-
VC395_RS16480431092..431337-246WP_001912198.1hypothetical protein-
VC395_RS16485431550..433298-1749WP_000063386.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron--344619..43048485865
flankIS/Tn--425852..426832980
-insideProphage--427343..47117843835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T23733 WP_000351248.1 NC_012583:428035-428436 [Vibrio cholerae O395]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T23733 NC_012583:428035-428436 [Vibrio cholerae O395]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT23733 WP_001047169.1 NC_012583:427343-428035 [Vibrio cholerae O395]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT23733 NC_012583:427343-428035 [Vibrio cholerae O395]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References