Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 404922..405326 Replicon chromosome II
Accession NC_012580
Organism Vibrio cholerae M66-2

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag VCM66_RS15420 Protein ID WP_001114075.1
Coordinates 405057..405326 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag VCM66_RS19440 Protein ID WP_099607150.1
Coordinates 404922..405026 (+) Length 35 a.a.

Genomic Context

VCM66_RS19595VCM66_RS15380VCM66_RS15385VCM66_RS15390VCM66_RS15395VCM66_RS15400VCM66_RS15405VCM66_RS15410VCM66_RS15415VCM66_RS19440VCM66_RS15420VCM66_RS15425VCM66_RS19445VCM66_RS15430VCM66_RS15445VCM66_RS15450VCM66_RS15435VCM66_RS15440
Location: 400164..400589 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 400586..401119 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 401321..401578 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 401566..401868 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 402022..402231 (210 bp)
Type: Others
Protein ID: Protein_419
Location: 402350..402787 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 402851..403069 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 403244..404116 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 404266..404865 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 404922..405026 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 405057..405326 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 405320..405841 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 406140..406265 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 406516..406911 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 407803..408318 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 408502..408915 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 407050..407328 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 407325..407609 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCM66_RS19595400164..400589+426WP_001882332.1DUF1778 domain-containing protein-
VCM66_RS15380400586..401119+534WP_000118351.1GNAT family N-acetyltransferase-
VCM66_RS15385401321..401578+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCM66_RS15390401566..401868+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
VCM66_RS15395402022..402231+210Protein_419GNAT family N-acetyltransferase-
VCM66_RS15400402350..402787+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
VCM66_RS15405402851..403069+219WP_071908318.1GNAT family N-acetyltransferase-
VCM66_RS15410403244..404116+873WP_000254716.1DUF3800 domain-containing protein-
VCM66_RS15415404266..404865+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VCM66_RS19440404922..405026+105WP_099607150.1acetyltransferaseAntitoxin
VCM66_RS15420405057..405326+270WP_001114075.1DUF4160 domain-containing proteinToxin
VCM66_RS15425405320..405841+522WP_000921691.1DUF2442 domain-containing protein-
VCM66_RS19445406140..406265+126WP_001905700.1DUF645 family protein-
VCM66_RS15430406516..406911+396WP_001000867.1hypothetical protein-
VCM66_RS15435407050..407328-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
VCM66_RS15440407325..407609-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
VCM66_RS15445407803..408318+516WP_000343779.1GNAT family N-acetyltransferase-
VCM66_RS15450408502..408915+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--305869..409778103909
-insideIntegron--310949..40940298453
flankIS/Tn--402350..402787437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T23719 WP_001114075.1 NC_012580:405057-405326 [Vibrio cholerae M66-2]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T23719 NC_012580:405057-405326 [Vibrio cholerae M66-2]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT23719 WP_099607150.1 NC_012580:404922-405026 [Vibrio cholerae M66-2]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT23719 NC_012580:404922-405026 [Vibrio cholerae M66-2]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References