Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 400164..401119 Replicon chromosome II
Accession NC_012580
Organism Vibrio cholerae M66-2

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag VCM66_RS15380 Protein ID WP_000118351.1
Coordinates 400586..401119 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag VCM66_RS19595 Protein ID WP_001882332.1
Coordinates 400164..400589 (+) Length 142 a.a.

Genomic Context

VCM66_RS15335VCM66_RS15340VCM66_RS15345VCM66_RS19005VCM66_RS15360VCM66_RS15365VCM66_RS15370VCM66_RS19595VCM66_RS15380VCM66_RS15385VCM66_RS15390VCM66_RS15395VCM66_RS15400VCM66_RS15405VCM66_RS15410VCM66_RS15415VCM66_RS19440VCM66_RS15420VCM66_RS15425VCM66_RS15350VCM66_RS15355
Location: 395694..395945 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 395935..396222 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 396350..396805 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 397127..397279 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 398478..399146 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 399298..399585 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 399726..400097 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 400164..400589 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 400586..401119 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 401321..401578 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 401566..401868 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 402022..402231 (210 bp)
Type: Others
Protein ID: Protein_419
Location: 402350..402787 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 402851..403069 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 403244..404116 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 404266..404865 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 404922..405026 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 405057..405326 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 405320..405841 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 397481..397978 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 397975..398247 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCM66_RS15335395694..395945+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCM66_RS15340395935..396222+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
VCM66_RS15345396350..396805+456WP_001245327.1GNAT family N-acetyltransferase-
VCM66_RS19005397127..397279+153WP_001884520.1DUF645 family protein-
VCM66_RS15350397481..397978-498WP_000982260.1GNAT family N-acetyltransferase-
VCM66_RS15355397975..398247-273WP_000246253.1DUF1778 domain-containing protein-
VCM66_RS15360398478..399146+669WP_000043871.1hypothetical protein-
VCM66_RS15365399298..399585+288WP_000426470.1hypothetical protein-
VCM66_RS15370399726..400097+372WP_001164080.1nucleotide pyrophosphohydrolase-
VCM66_RS19595400164..400589+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
VCM66_RS15380400586..401119+534WP_000118351.1GNAT family N-acetyltransferaseToxin
VCM66_RS15385401321..401578+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCM66_RS15390401566..401868+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
VCM66_RS15395402022..402231+210Protein_419GNAT family N-acetyltransferase-
VCM66_RS15400402350..402787+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
VCM66_RS15405402851..403069+219WP_071908318.1GNAT family N-acetyltransferase-
VCM66_RS15410403244..404116+873WP_000254716.1DUF3800 domain-containing protein-
VCM66_RS15415404266..404865+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VCM66_RS19440404922..405026+105WP_099607150.1acetyltransferase-
VCM66_RS15420405057..405326+270WP_001114075.1DUF4160 domain-containing protein-
VCM66_RS15425405320..405841+522WP_000921691.1DUF2442 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--305869..409778103909
-insideIntegron--310949..40940298453
flankIS/Tn--402350..402787437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T23717 WP_000118351.1 NC_012580:400586-401119 [Vibrio cholerae M66-2]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T23717 NC_012580:400586-401119 [Vibrio cholerae M66-2]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT23717 WP_001882332.1 NC_012580:400164-400589 [Vibrio cholerae M66-2]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT23717 NC_012580:400164-400589 [Vibrio cholerae M66-2]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References