22075

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 834163..834691 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag VC0395_RS03810 Protein ID WP_000221354.1
Coordinates 834163..834450 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag VC0395_RS03815 Protein ID WP_001250179.1
Coordinates 834440..834691 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC0395_RS03780 829664..830008 + 345 WP_001912196.1 hypothetical protein -
VC0395_RS03785 830312..830647 + 336 WP_000978438.1 hypothetical protein -
VC0395_RS03790 830644..832392 + 1749 WP_000063386.1 hypothetical protein -
VC0395_RS03795 832605..832850 + 246 WP_001912198.1 hypothetical protein -
VC0395_RS03800 833106..833258 - 153 WP_001884520.1 DUF645 family protein -
VC0395_RS03805 833580..834035 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
VC0395_RS03810 834163..834450 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VC0395_RS03815 834440..834691 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VC0395_RS03820 834905..835318 - 414 WP_000049417.1 VOC family protein -
VC0395_RS20535 835393..835536 - 144 WP_071908341.1 DUF3265 domain-containing protein -
VC0395_RS03825 835506..835907 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
VC0395_RS03830 835907..836599 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
VC0395_RS03835 836736..837042 - 307 Protein_739 CatB-related O-acetyltransferase -
VC0395_RS03840 837110..838090 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
VC0395_RS20945 838215..838370 - 156 WP_000751734.1 hypothetical protein -
VC0395_RS03850 838538..838972 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
VC0395_RS03855 839109..839423 - 315 WP_000071008.1 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 833458..916350 82892
flank IS/Tn - - 837110..838090 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T22075 WP_000221354.1 NC_009456:c834450-834163 [Vibrio cholerae O395]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T22075 NC_009456:c834450-834163 [Vibrio cholerae O395]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCCCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT22075 WP_001250179.1 NC_009456:c834691-834440 [Vibrio cholerae O395]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT22075 NC_009456:c834691-834440 [Vibrio cholerae O395]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References