Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 834163..834691 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag VC0395_RS03810 Protein ID WP_000221354.1
Coordinates 834163..834450 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag VC0395_RS03815 Protein ID WP_001250179.1
Coordinates 834440..834691 (-) Length 84 a.a.

Genomic Context

VC0395_RS03780VC0395_RS03785VC0395_RS03790VC0395_RS03795VC0395_RS03840VC0395_RS03800VC0395_RS03805VC0395_RS03810VC0395_RS03815VC0395_RS03820VC0395_RS20535VC0395_RS03825VC0395_RS03830VC0395_RS03835VC0395_RS20945VC0395_RS03850VC0395_RS03855
Location: 829664..830008 (345 bp)
Type: Others
Protein ID: WP_001912196.1
Location: 830312..830647 (336 bp)
Type: Others
Protein ID: WP_000978438.1
Location: 830644..832392 (1749 bp)
Type: Others
Protein ID: WP_000063386.1
Location: 832605..832850 (246 bp)
Type: Others
Protein ID: WP_001912198.1
Location: 837110..838090 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 833106..833258 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 833580..834035 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 834163..834450 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 834440..834691 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 834905..835318 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 835393..835536 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 835506..835907 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 835907..836599 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 836736..837042 (307 bp)
Type: Others
Protein ID: Protein_739
Location: 838215..838370 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 838538..838972 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 839109..839423 (315 bp)
Type: Others
Protein ID: WP_000071008.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VC0395_RS03780829664..830008+345WP_001912196.1hypothetical protein-
VC0395_RS03785830312..830647+336WP_000978438.1hypothetical protein-
VC0395_RS03790830644..832392+1749WP_000063386.1hypothetical protein-
VC0395_RS03795832605..832850+246WP_001912198.1hypothetical protein-
VC0395_RS03800833106..833258-153WP_001884520.1DUF645 family protein-
VC0395_RS03805833580..834035-456WP_001245327.1GNAT family N-acetyltransferase-
VC0395_RS03810834163..834450-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VC0395_RS03815834440..834691-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VC0395_RS03820834905..835318-414WP_000049417.1VOC family protein-
VC0395_RS20535835393..835536-144WP_071908341.1DUF3265 domain-containing protein-
VC0395_RS03825835506..835907-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
VC0395_RS03830835907..836599-693WP_001047169.1GNAT family N-acetyltransferase-
VC0395_RS03835836736..837042-307Protein_739CatB-related O-acetyltransferase-
VC0395_RS03840837110..838090+981WP_000019370.1IS5-like element ISVch5 family transposase-
VC0395_RS20945838215..838370-156WP_000751734.1hypothetical protein-
VC0395_RS03850838538..838972-435WP_000256036.1GNAT family N-acetyltransferase-
VC0395_RS03855839109..839423-315WP_000071008.1DNA-binding transcriptional regulator-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron--833458..91635082892
flankIS/Tn--837110..838090980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T22075 WP_000221354.1 NC_009456:c834450-834163 [Vibrio cholerae O395]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T22075 NC_009456:c834450-834163 [Vibrio cholerae O395]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCCCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT22075 WP_001250179.1 NC_009456:c834691-834440 [Vibrio cholerae O395]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT22075 NC_009456:c834691-834440 [Vibrio cholerae O395]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References