Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 810288..811243 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag VC0395_RS03650 Protein ID WP_000118351.1
Coordinates 810288..810821 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag VC0395_RS20930 Protein ID WP_001882332.1
Coordinates 810818..811243 (-) Length 142 a.a.

Genomic Context

VC0395_RS03675VC0395_RS03680VC0395_RS03685VC0395_RS03610VC0395_RS03615VC0395_RS03620VC0395_RS03625VC0395_RS03630VC0395_RS03635VC0395_RS03640VC0395_RS03645VC0395_RS03650VC0395_RS20930VC0395_RS03660VC0395_RS03665VC0395_RS03670
Location: 813160..813432 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 813429..813926 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 814223..814717 (495 bp)
Type: Others
Protein ID: WP_000477435.1
Location: 806191..806409 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 806473..806910 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 807029..807238 (210 bp)
Type: Others
Protein ID: Protein_694
Location: 807374..807763 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 807938..808180 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 808388..809305 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 809539..809841 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 809829..810086 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 810288..810821 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 810818..811243 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 811310..811681 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 811822..812109 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 812261..812929 (669 bp)
Type: Others
Protein ID: WP_000043871.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VC0395_RS03610806191..806409-219WP_071908318.1GNAT family N-acetyltransferase-
VC0395_RS03615806473..806910-438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
VC0395_RS03620807029..807238-210Protein_694GNAT family N-acetyltransferase-
VC0395_RS03625807374..807763-390WP_001081302.1hypothetical protein-
VC0395_RS03630807938..808180-243WP_000107462.1hypothetical protein-
VC0395_RS03635808388..809305-918WP_000186333.1alpha/beta hydrolase-
VC0395_RS03640809539..809841-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
VC0395_RS03645809829..810086-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VC0395_RS03650810288..810821-534WP_000118351.1GNAT family N-acetyltransferaseToxin
VC0395_RS20930810818..811243-426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
VC0395_RS03660811310..811681-372WP_001164080.1nucleotide pyrophosphohydrolase-
VC0395_RS03665811822..812109-288WP_000426470.1hypothetical protein-
VC0395_RS03670812261..812929-669WP_000043871.1hypothetical protein-
VC0395_RS03675813160..813432+273WP_000246253.1DUF1778 domain-containing protein-
VC0395_RS03680813429..813926+498WP_000982260.1GNAT family N-acetyltransferase-
VC0395_RS03685814223..814717+495WP_000477435.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--782136..81669334557
-insideIntegron--799858..81343213574
flankIS/Tn--806473..806910437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T22073 WP_000118351.1 NC_009456:c810821-810288 [Vibrio cholerae O395]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T22073 NC_009456:c810821-810288 [Vibrio cholerae O395]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT22073 WP_001882332.1 NC_009456:c811243-810818 [Vibrio cholerae O395]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT22073 NC_009456:c811243-810818 [Vibrio cholerae O395]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References