22072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 809539..810086 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag VC0395_RS03640 Protein ID WP_000229317.1
Coordinates 809539..809841 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag VC0395_RS03645 Protein ID WP_000861987.1
Coordinates 809829..810086 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC0395_RS03605 805144..806016 - 873 WP_000254716.1 DUF3800 domain-containing protein -
VC0395_RS03610 806191..806409 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
VC0395_RS03615 806473..806910 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
VC0395_RS03620 807029..807238 - 210 Protein_694 GNAT family N-acetyltransferase -
VC0395_RS03625 807374..807763 - 390 WP_001081302.1 hypothetical protein -
VC0395_RS03630 807938..808180 - 243 WP_000107462.1 hypothetical protein -
VC0395_RS03635 808388..809305 - 918 WP_000186333.1 alpha/beta hydrolase -
VC0395_RS03640 809539..809841 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VC0395_RS03645 809829..810086 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VC0395_RS03650 810288..810821 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
VC0395_RS20930 810818..811243 - 426 WP_001882332.1 DUF1778 domain-containing protein -
VC0395_RS03660 811310..811681 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
VC0395_RS03665 811822..812109 - 288 WP_000426470.1 hypothetical protein -
VC0395_RS03670 812261..812929 - 669 WP_000043871.1 hypothetical protein -
VC0395_RS03675 813160..813432 + 273 WP_000246253.1 DUF1778 domain-containing protein -
VC0395_RS03680 813429..813926 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
VC0395_RS03685 814223..814717 + 495 WP_000477435.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 782136..816693 34557
- inside Integron - - 799858..813432 13574
flank IS/Tn - - 806473..806910 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T22072 WP_000229317.1 NC_009456:c809841-809539 [Vibrio cholerae O395]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T22072 NC_009456:c809841-809539 [Vibrio cholerae O395]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT22072 WP_000861987.1 NC_009456:c810086-809829 [Vibrio cholerae O395]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT22072 NC_009456:c810086-809829 [Vibrio cholerae O395]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References