22070

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 803419..804203 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag VC0395_RS03595 Protein ID WP_001114075.1
Coordinates 803934..804203 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag VC0395_RS03590 Protein ID WP_000921691.1
Coordinates 803419..803940 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC0395_RS03555 800345..800758 - 414 WP_000049420.1 VOC family protein -
VC0395_RS03560 800942..801457 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
VC0395_RS03565 801651..801935 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
VC0395_RS03570 801932..802210 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
VC0395_RS03575 802349..802744 - 396 WP_001000867.1 hypothetical protein -
VC0395_RS20505 802995..803120 - 126 WP_001905700.1 DUF645 family protein -
VC0395_RS03590 803419..803940 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
VC0395_RS03595 803934..804203 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
VC0395_RS20695 804234..804338 - 105 WP_099607150.1 acetyltransferase -
VC0395_RS03600 804395..804994 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
VC0395_RS03605 805144..806016 - 873 WP_000254716.1 DUF3800 domain-containing protein -
VC0395_RS03610 806191..806409 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
VC0395_RS03615 806473..806910 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
VC0395_RS03620 807029..807238 - 210 Protein_694 GNAT family N-acetyltransferase -
VC0395_RS03625 807374..807763 - 390 WP_001081302.1 hypothetical protein -
VC0395_RS03630 807938..808180 - 243 WP_000107462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 782136..816693 34557
- inside Integron - - 799858..813432 13574
flank IS/Tn - - 806473..806910 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T22070 WP_001114075.1 NC_009456:c804203-803934 [Vibrio cholerae O395]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T22070 NC_009456:c804203-803934 [Vibrio cholerae O395]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT22070 WP_000921691.1 NC_009456:c803940-803419 [Vibrio cholerae O395]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT22070 NC_009456:c803940-803419 [Vibrio cholerae O395]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References