22069

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 801651..802210 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VC0395_RS03570 Protein ID WP_000578476.1
Coordinates 801932..802210 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VC0395_RS03565 Protein ID WP_000381183.1
Coordinates 801651..801935 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC0395_RS03530 796782..797189 + 408 WP_000022491.1 hypothetical protein -
VC0395_RS03535 797306..798250 + 945 WP_001027829.1 hypothetical protein -
VC0395_RS03540 798264..798533 + 270 WP_000402869.1 hypothetical protein -
VC0395_RS03555 800345..800758 - 414 WP_000049420.1 VOC family protein -
VC0395_RS03560 800942..801457 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
VC0395_RS03565 801651..801935 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VC0395_RS03570 801932..802210 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VC0395_RS03575 802349..802744 - 396 WP_001000867.1 hypothetical protein -
VC0395_RS20505 802995..803120 - 126 WP_001905700.1 DUF645 family protein -
VC0395_RS03590 803419..803940 - 522 WP_000921691.1 DUF2442 domain-containing protein -
VC0395_RS03595 803934..804203 - 270 WP_001114075.1 DUF4160 domain-containing protein -
VC0395_RS20695 804234..804338 - 105 WP_099607150.1 acetyltransferase -
VC0395_RS03600 804395..804994 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
VC0395_RS03605 805144..806016 - 873 WP_000254716.1 DUF3800 domain-containing protein -
VC0395_RS03610 806191..806409 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
VC0395_RS03615 806473..806910 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 782136..816693 34557
- inside Integron - - 799858..813432 13574
flank IS/Tn - - 806473..806910 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T22069 WP_000578476.1 NC_009456:801932-802210 [Vibrio cholerae O395]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T22069 NC_009456:801932-802210 [Vibrio cholerae O395]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT22069 WP_000381183.1 NC_009456:801651-801935 [Vibrio cholerae O395]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT22069 NC_009456:801651-801935 [Vibrio cholerae O395]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References