Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 801651..802210 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VC0395_RS03570 Protein ID WP_000578476.1
Coordinates 801932..802210 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VC0395_RS03565 Protein ID WP_000381183.1
Coordinates 801651..801935 (+) Length 95 a.a.

Genomic Context

VC0395_RS03530VC0395_RS03535VC0395_RS03540VC0395_RS03565VC0395_RS03570VC0395_RS03555VC0395_RS03560VC0395_RS03575VC0395_RS20505VC0395_RS03590VC0395_RS03595VC0395_RS20695VC0395_RS03600VC0395_RS03605VC0395_RS03610VC0395_RS03615
Location: 796782..797189 (408 bp)
Type: Others
Protein ID: WP_000022491.1
Location: 797306..798250 (945 bp)
Type: Others
Protein ID: WP_001027829.1
Location: 798264..798533 (270 bp)
Type: Others
Protein ID: WP_000402869.1
Location: 801651..801935 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 801932..802210 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 800345..800758 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 800942..801457 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 802349..802744 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 802995..803120 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 803419..803940 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 803934..804203 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 804234..804338 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 804395..804994 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 805144..806016 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 806191..806409 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 806473..806910 (438 bp)
Type: Others
Protein ID: WP_000503164.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VC0395_RS03530796782..797189+408WP_000022491.1hypothetical protein-
VC0395_RS03535797306..798250+945WP_001027829.1hypothetical protein-
VC0395_RS03540798264..798533+270WP_000402869.1hypothetical protein-
VC0395_RS03555800345..800758-414WP_000049420.1VOC family protein-
VC0395_RS03560800942..801457-516WP_000343779.1GNAT family N-acetyltransferase-
VC0395_RS03565801651..801935+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VC0395_RS03570801932..802210+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VC0395_RS03575802349..802744-396WP_001000867.1hypothetical protein-
VC0395_RS20505802995..803120-126WP_001905700.1DUF645 family protein-
VC0395_RS03590803419..803940-522WP_000921691.1DUF2442 domain-containing protein-
VC0395_RS03595803934..804203-270WP_001114075.1DUF4160 domain-containing protein-
VC0395_RS20695804234..804338-105WP_099607150.1acetyltransferase-
VC0395_RS03600804395..804994-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VC0395_RS03605805144..806016-873WP_000254716.1DUF3800 domain-containing protein-
VC0395_RS03610806191..806409-219WP_071908318.1GNAT family N-acetyltransferase-
VC0395_RS03615806473..806910-438WP_000503164.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--782136..81669334557
-insideIntegron--799858..81343213574
flankIS/Tn--806473..806910437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T22069 WP_000578476.1 NC_009456:801932-802210 [Vibrio cholerae O395]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T22069 NC_009456:801932-802210 [Vibrio cholerae O395]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT22069 WP_000381183.1 NC_009456:801651-801935 [Vibrio cholerae O395]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT22069 NC_009456:801651-801935 [Vibrio cholerae O395]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References