Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1414434..1414805 Replicon chromosome
Accession NZ_CP084893
Organism Escherichia coli strain g94

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag LHV66_RS06985 Protein ID WP_001317028.1
Coordinates 1414611..1414805 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1414434..1414612 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHV66_RS06960 (1410389) 1410389..1411762 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
LHV66_RS06965 (1411891) 1411891..1412826 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
LHV66_RS06970 (1412878) 1412878..1414113 - 1236 WP_000040852.1 site-specific integrase -
LHV66_RS06975 (1414115) 1414115..1414330 - 216 WP_000079604.1 excisionase XisR -
- (1414434) 1414434..1414612 + 179 NuclAT_0 - Antitoxin
- (1414434) 1414434..1414612 + 179 NuclAT_0 - Antitoxin
- (1414434) 1414434..1414612 + 179 NuclAT_0 - Antitoxin
- (1414434) 1414434..1414612 + 179 NuclAT_0 - Antitoxin
LHV66_RS06980 (1414409) 1414409..1414618 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
LHV66_RS06985 (1414611) 1414611..1414805 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
LHV66_RS06990 (1414862) 1414862..1415671 - 810 WP_000166319.1 recombination protein RecT -
LHV66_RS06995 (1415664) 1415664..1418264 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
LHV66_RS07000 (1418366) 1418366..1418641 - 276 WP_000632297.1 protein RacC -
LHV66_RS07005 (1418716) 1418716..1418886 - 171 WP_001352098.1 YdaE family protein -
LHV66_RS07010 (1418886) 1418886..1419107 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1405619..1434552 28933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T219821 WP_001317028.1 NZ_CP084893:c1414805-1414611 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T219821 NZ_CP116721:c5640704-5640522 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA

Antitoxin


Download         Length: 179 bp

>AT219821 NZ_CP084893:1414434-1414612 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References