Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1413554..1413925 Replicon chromosome
Accession NZ_CP083410
Organism Escherichia coli strain RP437

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag LAJ62_RS06975 Protein ID WP_001317028.1
Coordinates 1413731..1413925 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1413554..1413732 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ62_RS06950 (1409509) 1409509..1410882 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
LAJ62_RS06955 (1411011) 1411011..1411946 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
LAJ62_RS06960 (1411998) 1411998..1413233 - 1236 WP_000040852.1 site-specific integrase -
LAJ62_RS06965 (1413235) 1413235..1413450 - 216 WP_000079604.1 excisionase XisR -
- (1413554) 1413554..1413732 + 179 NuclAT_0 - Antitoxin
- (1413554) 1413554..1413732 + 179 NuclAT_0 - Antitoxin
- (1413554) 1413554..1413732 + 179 NuclAT_0 - Antitoxin
- (1413554) 1413554..1413732 + 179 NuclAT_0 - Antitoxin
LAJ62_RS06970 (1413529) 1413529..1413738 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
LAJ62_RS06975 (1413731) 1413731..1413925 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
LAJ62_RS06980 (1413982) 1413982..1414791 - 810 WP_000166319.1 recombination protein RecT -
LAJ62_RS06985 (1414784) 1414784..1417384 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
LAJ62_RS06990 (1417486) 1417486..1417761 - 276 WP_000632297.1 protein RacC -
LAJ62_RS06995 (1417836) 1417836..1418006 - 171 WP_001352098.1 YdaE family protein -
LAJ62_RS07000 (1418006) 1418006..1418227 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1411998..1433672 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T216365 WP_001317028.1 NZ_CP083410:c1413925-1413731 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T216365 NZ_CP113029:835189-835296 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 179 bp

>AT216365 NZ_CP083410:1413554-1413732 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References