Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) TMCS/-
Location 1502987..1503566 Replicon chromosome
Accession NC_007795
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name MW1434 Uniprot ID Q2FY92
Locus tag SAOUHSC_01573 Protein ID YP_500088.1
Coordinates 1503321..1503566 (-) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 1502987..1503352 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAOUHSC_01565 1499730..1500287 - 558 YP_500080.1 hypothetical protein -
SAOUHSC_01566 1500313..1501479 - 1167 YP_500081.1 phi APSE P51-like protein -
SAOUHSC_01567 1501476..1501838 - 363 YP_500082.1 hypothetical protein -
SAOUHSC_01568 1501853..1502176 - 324 YP_500083.1 hypothetical protein -
SAOUHSC_01569 1502255..1502416 - 162 YP_500084.1 hypothetical protein -
SAOUHSC_01570 1502429..1502692 - 264 YP_500085.1 PVL orf 37-like protein -
SAOUHSC_01571 1502717..1502932 - 216 YP_500086.1 SLT orf 71-like protein -
SAOUHSC_01572 1502987..1503352 + 366 YP_500087.1 hypothetical protein Antitoxin
SAOUHSC_01573 1503321..1503566 - 246 YP_500088.1 hypothetical protein Toxin
SAOUHSC_01574 1503582..1503845 - 264 YP_500089.1 helix-turn-helix domain-containing protein -
SAOUHSC_A01514 1503842..1504015 - 174 YP_500090.1 hypothetical protein -
SAOUHSC_01575 1503978..1504691 + 714 YP_500091.1 helix-turn-helix domain-containing protein -
SAOUHSC_01576 1504707..1505639 + 933 YP_500092.1 exonuclease family protein -
SAOUHSC_01577 1505645..1505986 + 342 YP_500093.1 hypothetical protein -
SAOUHSC_01578 1506145..1506372 + 228 YP_500094.1 hypothetical protein -
SAOUHSC_01579 1506409..1506555 + 147 YP_500095.1 hypothetical protein -
SAOUHSC_01580 1506552..1507166 - 615 YP_500096.1 phi PVL ORF 30-like protein -
SAOUHSC_01582 1507292..1508497 + 1206 YP_500097.1 bacteriophage integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1462371..1521253 58882


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF2829

(2-69)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9434.70 Da        Isoelectric Point: 5.7783

>T21483 YP_500088.1 NC_007795:c1503566-1503321 [Staphylococcus aureus subsp. aureus NCTC 8325]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
L

Download         Length: 246 bp

>T21483 NC_007795:c1503566-1503321 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTATAG

Antitoxin


Download         Length: 366 bp

>AT21483 NC_007795:1502987-1503352 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGATTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTATAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2FY92

Antitoxin

Download structure file

References