Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) TMCS/-
Location 1511610..1512189 Replicon chromosome
Accession NZ_LS483365
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name MW1434 Uniprot ID Q2FY92
Locus tag DQM91_RS07620 Protein ID WP_001025402.1
Coordinates 1511944..1512189 (-) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 1511610..1511975 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM91_RS07580 1508353..1508910 - 558 WP_000645042.1 DUF2815 family protein -
DQM91_RS07585 1508936..1510102 - 1167 WP_000762540.1 DUF2800 domain-containing protein -
DQM91_RS07590 1510099..1510461 - 363 WP_000279452.1 hypothetical protein -
DQM91_RS07595 1510476..1510799 - 324 WP_000174996.1 hypothetical protein -
DQM91_RS07600 1510878..1511039 - 162 WP_001285961.1 DUF1270 domain-containing protein -
DQM91_RS07605 1511052..1511315 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
DQM91_RS07610 1511340..1511555 - 216 WP_001097552.1 hypothetical protein -
DQM91_RS07615 1511610..1511975 + 366 WP_001131647.1 hypothetical protein Antitoxin
DQM91_RS07620 1511944..1512189 - 246 WP_001025402.1 DUF2829 domain-containing protein Toxin
DQM91_RS07625 1512205..1512468 - 264 WP_000854072.1 helix-turn-helix domain-containing protein -
DQM91_RS07630 1512465..1512638 - 174 WP_001801500.1 hypothetical protein -
DQM91_RS07635 1512601..1513314 + 714 WP_001031454.1 XRE family transcriptional regulator -
DQM91_RS07640 1513330..1514262 + 933 WP_000759682.1 ATP-dependent helicase -
DQM91_RS07645 1514268..1514609 + 342 WP_000591749.1 hypothetical protein -
DQM91_RS07650 1514813..1514995 + 183 WP_000705240.1 hypothetical protein -
DQM91_RS07655 1515032..1515178 + 147 WP_001013104.1 hypothetical protein -
DQM91_RS07660 1515175..1515789 - 615 WP_000191459.1 hypothetical protein -
DQM91_RS07665 1515915..1517120 + 1206 WP_000264748.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - gnd 1470996..1539708 68712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF2829

(2-69)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9434.70 Da        Isoelectric Point: 5.7783

>T292430 WP_001025402.1 NZ_LS483365:c1512189-1511944 [Staphylococcus aureus subsp. aureus NCTC 8325]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
L

Download         Length: 246 bp

Antitoxin


Download         Length: 366 bp

>AT292430 NZ_LS483365:1511610-1511975 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGATTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTATAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2FY92

Antitoxin

Download structure file

References