123564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1603375..1604172 Replicon chromosome
Accession NZ_CP039156
Organism Staphylococcus aureus strain WCUH29

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag E5491_RS08070 Protein ID WP_000525014.1
Coordinates 1603711..1604172 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag E5491_RS08065 Protein ID WP_001260486.1
Coordinates 1603375..1603698 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5491_RS08015 1599111..1599668 - 558 WP_000645042.1 DUF2815 family protein -
E5491_RS08020 1599694..1600860 - 1167 WP_047216521.1 DUF2800 domain-containing protein -
E5491_RS08025 1600857..1601219 - 363 WP_135783508.1 hypothetical protein -
E5491_RS08030 1601234..1601557 - 324 WP_000174994.1 hypothetical protein -
E5491_RS08035 1601636..1601797 - 162 WP_001285963.1 DUF1270 family protein -
E5491_RS08040 1601810..1602073 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
E5491_RS08045 1602098..1602313 - 216 WP_001036302.1 hypothetical protein -
E5491_RS08050 1602368..1602733 + 366 WP_001128433.1 hypothetical protein -
E5491_RS08055 1602702..1602947 - 246 WP_001025401.1 DUF2829 domain-containing protein -
E5491_RS08060 1602963..1603211 - 249 WP_000272861.1 helix-turn-helix domain-containing protein -
E5491_RS08065 1603375..1603698 + 324 WP_001260486.1 helix-turn-helix domain-containing protein Antitoxin
E5491_RS08070 1603711..1604172 + 462 WP_000525014.1 hypothetical protein Toxin
E5491_RS08075 1604189..1604623 + 435 WP_047216523.1 hypothetical protein -
E5491_RS08080 1604652..1605047 + 396 WP_000449655.1 hypothetical protein -
E5491_RS08085 1605137..1605283 + 147 WP_001795334.1 hypothetical protein -
E5491_RS08090 1605280..1605894 - 615 WP_000191463.1 hypothetical protein -
E5491_RS08095 1606020..1607225 + 1206 WP_000264751.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1561745..1619977 58232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18104.44 Da        Isoelectric Point: 4.6915

>T123564 WP_000525014.1 NZ_CP039156:1603711-1604172 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Download         Length: 462 bp

>T123564 NZ_CP039156:1603711-1604172 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAACCGTTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12427.10 Da        Isoelectric Point: 9.3811

>AT123564 WP_001260486.1 NZ_CP039156:1603375-1603698 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT123564 NZ_CP039156:1603375-1603698 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References