Detailed information of TA system TA068898

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1501781..1502360
• Replicon: chromosome
• Accession: NZ_CP018205
• Organism: Staphylococcus aureus strain HG001 isolate RN1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: Q2FY92
• Locus tag: BSR30_RS07605
• Protein ID: WP_001025402.1
• Coordinates: 1502115..1502360 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1501781..1502146 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSR30_RS07565	1498524..1499081	-	558	WP_000645042.1	DUF2815 family protein	-
BSR30_RS07570	1499107..1500273	-	1167	WP_000762540.1	DUF2800 domain-containing protein	-
BSR30_RS07575	1500270..1500632	-	363	WP_000279452.1	hypothetical protein	-
BSR30_RS07580	1500647..1500970	-	324	WP_000174996.1	hypothetical protein	-
BSR30_RS07585	1501049..1501210	-	162	WP_001285961.1	DUF1270 domain-containing protein	-
BSR30_RS07590	1501223..1501486	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
BSR30_RS07595	1501511..1501726	-	216	WP_001097552.1	hypothetical protein	-
BSR30_RS07600	1501781..1502146	+	366	WP_001131647.1	hypothetical protein	Antitoxin
BSR30_RS07605	1502115..1502360	-	246	WP_001025402.1	DUF2829 domain-containing protein	Toxin
BSR30_RS07610	1502376..1502639	-	264	WP_000854072.1	helix-turn-helix domain-containing protein	-
BSR30_RS07615	1502636..1502809	-	174	WP_001801500.1	hypothetical protein	-
BSR30_RS07620	1502772..1503485	+	714	WP_001031454.1	XRE family transcriptional regulator	-
BSR30_RS07625	1503501..1504433	+	933	WP_000759682.1	ATP-dependent helicase	-
BSR30_RS07630	1504439..1504780	+	342	WP_000591749.1	hypothetical protein	-
BSR30_RS07635	1504984..1505166	+	183	WP_000705240.1	hypothetical protein	-
BSR30_RS07640	1505203..1505349	+	147	WP_001013104.1	hypothetical protein	-
BSR30_RS07645	1505346..1505960	-	615	WP_000191459.1	hypothetical protein	-
BSR30_RS07650	1506086..1507291	+	1206	WP_000264748.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_007795 Staphylococcus aureus subsp. aureus NCTC 8325 Prophage TA021483 1462371..1521253 0.003	inside	Prophage	-	gnd	1461167..1529879	68712

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9434.70 Da
• Isoelectric Point: 5.7783

>T68898 WP_001025402.1 NZ_CP018205:c1502360-1502115 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
L

Nucleotide

• Length: 246 bp

>T68898 NZ_CP018205:c1502360-1502115 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTATAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT68898 NZ_CP018205:1501781-1502146 [Staphylococcus aureus]
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGATTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTATAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: Q2FY92

Antitoxin