Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) TMCS/-
Location 1501781..1502360 Replicon chromosome
Accession NZ_CP018205
Organism Staphylococcus aureus strain HG001 isolate RN1

Toxin (Protein)


Gene name MW1434 Uniprot ID Q2FY92
Locus tag BSR30_RS07605 Protein ID WP_001025402.1
Coordinates 1502115..1502360 (-) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 1501781..1502146 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSR30_RS07565 1498524..1499081 - 558 WP_000645042.1 DUF2815 family protein -
BSR30_RS07570 1499107..1500273 - 1167 WP_000762540.1 DUF2800 domain-containing protein -
BSR30_RS07575 1500270..1500632 - 363 WP_000279452.1 hypothetical protein -
BSR30_RS07580 1500647..1500970 - 324 WP_000174996.1 hypothetical protein -
BSR30_RS07585 1501049..1501210 - 162 WP_001285961.1 DUF1270 domain-containing protein -
BSR30_RS07590 1501223..1501486 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
BSR30_RS07595 1501511..1501726 - 216 WP_001097552.1 hypothetical protein -
BSR30_RS07600 1501781..1502146 + 366 WP_001131647.1 hypothetical protein Antitoxin
BSR30_RS07605 1502115..1502360 - 246 WP_001025402.1 DUF2829 domain-containing protein Toxin
BSR30_RS07610 1502376..1502639 - 264 WP_000854072.1 helix-turn-helix domain-containing protein -
BSR30_RS07615 1502636..1502809 - 174 WP_001801500.1 hypothetical protein -
BSR30_RS07620 1502772..1503485 + 714 WP_001031454.1 XRE family transcriptional regulator -
BSR30_RS07625 1503501..1504433 + 933 WP_000759682.1 ATP-dependent helicase -
BSR30_RS07630 1504439..1504780 + 342 WP_000591749.1 hypothetical protein -
BSR30_RS07635 1504984..1505166 + 183 WP_000705240.1 hypothetical protein -
BSR30_RS07640 1505203..1505349 + 147 WP_001013104.1 hypothetical protein -
BSR30_RS07645 1505346..1505960 - 615 WP_000191459.1 hypothetical protein -
BSR30_RS07650 1506086..1507291 + 1206 WP_000264748.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - gnd 1461167..1529879 68712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF2829

(2-69)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9434.70 Da        Isoelectric Point: 5.7783

>T68898 WP_001025402.1 NZ_CP018205:c1502360-1502115 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
L

Download         Length: 246 bp

>T68898 NZ_CP018205:c1502360-1502115 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTATAG

Antitoxin


Download         Length: 366 bp

>AT68898 NZ_CP018205:1501781-1502146 [Staphylococcus aureus]
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGATTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTATAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2FY92

Antitoxin

Download structure file

References