20999

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2158730..2159358 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name higB Uniprot ID Q7N5W8
Locus tag PLU_RS09050 Protein ID WP_011146088.1
Coordinates 2158730..2159017 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PLU_RS09055 Protein ID WP_011146089.1
Coordinates 2159032..2159358 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS09025 (plu1806) 2154077..2155588 - 1512 WP_011146083.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
PLU_RS09030 (plu1807) 2155892..2156725 + 834 WP_011146084.1 MurR/RpiR family transcriptional regulator -
PLU_RS09035 (plu1808) 2156934..2157293 + 360 WP_011146085.1 hypothetical protein -
PLU_RS09040 (plu1809) 2157563..2157898 + 336 WP_011146086.1 tRNA-binding protein -
PLU_RS09045 (plu1810) 2157955..2158662 + 708 WP_011146087.1 AraC family transcriptional regulator -
PLU_RS09050 (plu1811) 2158730..2159017 + 288 WP_011146088.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PLU_RS09055 (plu1812) 2159032..2159358 + 327 WP_011146089.1 HigA family addiction module antidote protein Antitoxin
PLU_RS09060 (plu1813) 2159566..2161104 - 1539 WP_011146090.1 peptide MFS transporter -
PLU_RS09065 (plu1814) 2161828..2162769 - 942 WP_011146091.1 LpxL/LpxP family Kdo(2)-lipid IV(A) lauroyl/palmitoleoyl acyltransferasee -
PLU_RS09070 (plu1815) 2163056..2163292 + 237 WP_011146092.1 DinI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2130712..2182848 52136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-98)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11360.00 Da        Isoelectric Point: 7.2395

>T20999 WP_011146088.1 NC_005126:2158730-2159017 [Photorhabdus laumondii subsp. laumondii TTO1]
MAVEFRDGWLERFYEQDLPHKCIPASLQRALYRKLQILDASVKEADLRIPPGNHFEYLNGYLRGWCSIRVNKQYRLIFQW
IDGIAVDTYLDPHNY

Download         Length: 288 bp

>T20999 NC_005126:2158730-2159017 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGCTGTTGAATTCAGGGATGGATGGCTAGAAAGATTTTATGAACAAGATTTACCGCACAAATGCATACCTGCATCTTT
ACAGCGTGCGTTATACAGAAAACTACAAATTTTGGATGCTTCGGTTAAAGAGGCTGATTTAAGAATCCCTCCGGGAAACC
ATTTTGAATACTTGAATGGCTATTTGAGGGGATGGTGCTCAATAAGAGTAAATAAGCAATATAGGCTTATTTTTCAATGG
ATTGATGGTATTGCGGTTGATACATATCTGGATCCTCATAACTATTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12040.07 Da        Isoelectric Point: 9.9254

>AT20999 WP_011146089.1 NC_005126:2159032-2159358 [Photorhabdus laumondii subsp. laumondii TTO1]
MMRNTKRRPATVGEILVSEFLVPLNIEINVLAEAMGVHRNTLSRIVHDKGSLTVPMAIKLAAALGNTAEFWLNIQHSVEL
WDVRNHAYQAESLNVKQIVKLSVTAAMH

Download         Length: 327 bp

>AT20999 NC_005126:2159032-2159358 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGATGAGGAATACAAAACGTCGCCCTGCAACAGTGGGTGAAATATTGGTGAGTGAGTTTCTGGTGCCTTTGAATATCGA
AATTAATGTGCTTGCGGAAGCTATGGGTGTTCACCGCAATACATTAAGTAGAATTGTGCATGATAAAGGTTCGCTAACCG
TTCCTATGGCGATCAAATTGGCAGCGGCTTTGGGCAATACAGCGGAGTTTTGGCTTAATATTCAACATTCAGTTGAACTG
TGGGATGTGCGTAATCATGCCTATCAAGCGGAATCACTGAATGTAAAACAGATAGTTAAGCTATCAGTTACAGCGGCAAT
GCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7N5W8

Antitoxin

Source ID Structure

References