89201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2158731..2159359 Replicon chromosome
Accession NZ_CP024901
Organism Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)


Gene name higB Uniprot ID Q7N5W8
Locus tag PluTT01m_RS09370 Protein ID WP_011146088.1
Coordinates 2158731..2159018 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PluTT01m_RS09375 Protein ID WP_011146089.1
Coordinates 2159033..2159359 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluTT01m_RS09345 2154078..2155589 - 1512 WP_011146083.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
PluTT01m_RS09350 2155893..2156726 + 834 WP_011146084.1 MurR/RpiR family transcriptional regulator -
PluTT01m_RS09355 2156935..2157294 + 360 WP_011146085.1 hypothetical protein -
PluTT01m_RS09360 2157564..2157899 + 336 WP_011146086.1 tRNA-binding protein -
PluTT01m_RS09365 2157956..2158663 + 708 WP_011146087.1 AraC family transcriptional regulator -
PluTT01m_RS09370 2158731..2159018 + 288 WP_011146088.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PluTT01m_RS09375 2159033..2159359 + 327 WP_011146089.1 HigA family addiction module antidote protein Antitoxin
PluTT01m_RS09380 2159567..2161105 - 1539 WP_011146090.1 peptide MFS transporter -
PluTT01m_RS09385 2161829..2162770 - 942 WP_011146091.1 LpxL/LpxP family Kdo(2)-lipid IV(A) lauroyl/palmitoleoyl acyltransferasee -
PluTT01m_RS09390 2163057..2163293 + 237 WP_011146092.1 DinI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2130713..2182849 52136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-98)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11360.00 Da        Isoelectric Point: 7.2395

>T89201 WP_011146088.1 NZ_CP024901:2158731-2159018 [Photorhabdus laumondii subsp. laumondii]
MAVEFRDGWLERFYEQDLPHKCIPASLQRALYRKLQILDASVKEADLRIPPGNHFEYLNGYLRGWCSIRVNKQYRLIFQW
IDGIAVDTYLDPHNY

Download         Length: 288 bp

>T89201 NZ_CP024901:2158731-2159018 [Photorhabdus laumondii subsp. laumondii]
ATGGCTGTTGAATTCAGGGATGGATGGCTAGAAAGATTTTATGAACAAGATTTACCGCACAAATGCATACCTGCATCTTT
ACAGCGTGCGTTATACAGAAAACTACAAATTTTGGATGCTTCGGTTAAAGAGGCTGATTTAAGAATCCCTCCGGGAAACC
ATTTTGAATACTTGAATGGCTATTTGAGGGGATGGTGCTCAATAAGAGTAAATAAGCAATATAGGCTTATTTTTCAATGG
ATTGATGGTATTGCGGTTGATACATATCTGGATCCTCATAACTATTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12040.07 Da        Isoelectric Point: 9.9254

>AT89201 WP_011146089.1 NZ_CP024901:2159033-2159359 [Photorhabdus laumondii subsp. laumondii]
MMRNTKRRPATVGEILVSEFLVPLNIEINVLAEAMGVHRNTLSRIVHDKGSLTVPMAIKLAAALGNTAEFWLNIQHSVEL
WDVRNHAYQAESLNVKQIVKLSVTAAMH

Download         Length: 327 bp

>AT89201 NZ_CP024901:2159033-2159359 [Photorhabdus laumondii subsp. laumondii]
ATGATGAGGAATACAAAACGTCGCCCTGCAACAGTGGGTGAAATATTGGTGAGTGAGTTTCTGGTGCCTTTGAATATCGA
AATTAATGTGCTTGCGGAAGCTATGGGTGTTCACCGCAATACATTAAGTAGAATTGTGCATGATAAAGGTTCGCTAACCG
TTCCTATGGCGATCAAATTGGCAGCGGCTTTGGGCAATACAGCGGAGTTTTGGCTTAATATTCAACATTCAGTTGAACTG
TGGGATGTGCGTAATCATGCCTATCAAGCGGAATCACTGAATGTAAAACAGATAGTTAAGCTATCAGTTACAGCGGCAAT
GCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7N5W8

Antitoxin

Source ID Structure

References