62840

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2158730..2159358 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name higB Uniprot ID A0A6L9JDM3
Locus tag A4R40_RS09355 Protein ID WP_058589469.1
Coordinates 2158730..2159017 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A4R40_RS09360 Protein ID WP_011146089.1
Coordinates 2159032..2159358 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS09330 2154077..2155588 - 1512 WP_109791486.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
A4R40_RS09335 2155892..2156725 + 834 WP_011146084.1 MurR/RpiR family transcriptional regulator -
A4R40_RS09340 2156934..2157293 + 360 WP_058589470.1 hypothetical protein -
A4R40_RS09345 2157563..2157898 + 336 WP_011146086.1 tRNA-binding protein -
A4R40_RS09350 2157955..2158662 + 708 WP_058589488.1 AraC family transcriptional regulator -
A4R40_RS09355 2158730..2159017 + 288 WP_058589469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS09360 2159032..2159358 + 327 WP_011146089.1 HigA family addiction module antidote protein Antitoxin
A4R40_RS09365 2159566..2161104 - 1539 WP_011146090.1 peptide MFS transporter -
A4R40_RS09370 2161828..2162769 - 942 WP_109791487.1 LpxL/LpxP family Kdo(2)-lipid IV(A) lauroyl/palmitoleoyl acyltransferasee -
A4R40_RS09375 2163056..2163292 + 237 WP_011146092.1 DinI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2130712..2182848 52136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-98)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11411.05 Da        Isoelectric Point: 7.2406

>T62840 WP_058589469.1 NZ_CP015281:2158730-2159017 [Photorhabdus laumondii subsp. laumondii]
MAVEFRDRWLERFYEQDLPHKCIPASLQRALYRKLQILDASVKEADLRIPPGNHFEYLNGYLRGWCSIRVNKQYRLIFQW
IDGIAVDTYLDPHND

Download         Length: 288 bp

>T62840 NZ_CP015281:2158730-2159017 [Photorhabdus laumondii subsp. laumondii]
ATGGCTGTTGAATTCAGGGATAGATGGCTAGAAAGATTTTATGAACAAGATTTACCGCACAAATGCATACCTGCATCTTT
ACAGCGTGCGTTATACAGAAAACTACAAATTTTGGATGCTTCGGTTAAAGAGGCTGATTTAAGAATCCCTCCGGGAAACC
ATTTTGAATACTTGAATGGCTATTTGAGGGGATGGTGCTCAATAAGAGTAAATAAGCAATATAGGCTTATTTTTCAATGG
ATTGATGGTATTGCGGTTGATACATATCTGGATCCTCATAACGATTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12040.07 Da        Isoelectric Point: 9.9254

>AT62840 WP_011146089.1 NZ_CP015281:2159032-2159358 [Photorhabdus laumondii subsp. laumondii]
MMRNTKRRPATVGEILVSEFLVPLNIEINVLAEAMGVHRNTLSRIVHDKGSLTVPMAIKLAAALGNTAEFWLNIQHSVEL
WDVRNHAYQAESLNVKQIVKLSVTAAMH

Download         Length: 327 bp

>AT62840 NZ_CP015281:2159032-2159358 [Photorhabdus laumondii subsp. laumondii]
ATGATGAGGAATACAAAACGTCGCCCTGCAACAGTGGGTGAAATATTGGTGAGTGAGTTTCTGGTGCCTTTGAATATCGA
AATTAATGTGCTTGCGGAAGCTATGGGTGTTCACCGCAATACATTAAGTAGAATTGTGCATGATAAAGGTTCGCTAACCG
TTCCTATGGCGATCAAATTGGCAGCGGCTTTGGGCAATACAGCGGAGTTTTGGCTTAATATTCAACATTCAGTTGAACTG
TGGGATGTGCGTAATCATGCCTATCAAGCGGAATCACTGAATGTAAAACAGATAGTTAAGCTATCAGTTACAGCGGCAAT
GCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JDM3

Antitoxin

Source ID Structure

References