206615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 1039979..1040763 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag J3992_RS18515 Protein ID WP_001114075.1
Coordinates 1040494..1040763 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag J3992_RS18510 Protein ID WP_000921691.1
Coordinates 1039979..1040500 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS18480 (J3992_18460) 1036905..1037318 - 414 WP_000049420.1 VOC family protein -
J3992_RS18485 (J3992_18465) 1037502..1038017 - 516 WP_000343779.1 GNAT family protein -
J3992_RS18490 (J3992_18470) 1038211..1038495 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
J3992_RS18495 (J3992_18475) 1038492..1038770 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
J3992_RS18500 (J3992_18480) 1038909..1039304 - 396 WP_001000867.1 hypothetical protein -
J3992_RS18505 (J3992_18485) 1039555..1039680 - 126 WP_001905700.1 DUF645 family protein -
J3992_RS18510 (J3992_18490) 1039979..1040500 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
J3992_RS18515 (J3992_18495) 1040494..1040763 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
J3992_RS18520 (J3992_18500) 1040830..1040898 - 69 Protein_1000 acetyltransferase -
J3992_RS18525 (J3992_18505) 1040955..1041554 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
J3992_RS18530 (J3992_18510) 1041704..1042576 - 873 WP_000254716.1 DUF3800 domain-containing protein -
J3992_RS18535 (J3992_18515) 1042751..1042972 - 222 Protein_1003 GNAT family N-acetyltransferase -
J3992_RS18540 (J3992_18520) 1043033..1043470 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
J3992_RS18545 (J3992_18525) 1043589..1043798 - 210 Protein_1005 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172
flank IS/Tn - - 1043033..1043470 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T206615 WP_001114075.1 NZ_CP077061:c1040763-1040494 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T206615 NZ_CP102503:c13422-13006 [Citrobacter youngae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT206615 WP_000921691.1 NZ_CP077061:c1040500-1039979 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT206615 NZ_CP102503:c13649-13419 [Citrobacter youngae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References