Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1038211..1038770 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag J3992_RS18495 Protein ID WP_000578476.1
Coordinates 1038492..1038770 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag J3992_RS18490 Protein ID WP_000381183.1
Coordinates 1038211..1038495 (+) Length 95 a.a.

Genomic Context

J3992_RS18490J3992_RS18495J3992_RS18480J3992_RS18485J3992_RS18500J3992_RS18505J3992_RS18510J3992_RS18515J3992_RS18520J3992_RS18525J3992_RS18530J3992_RS18535J3992_RS18540
Location: 1038211..1038495 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 1038492..1038770 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 1036905..1037318 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 1037502..1038017 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 1038909..1039304 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 1039555..1039680 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 1039979..1040500 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 1040494..1040763 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 1040830..1040898 (69 bp)
Type: Others
Protein ID: Protein_1000
Location: 1040955..1041554 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 1041704..1042576 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 1042751..1042972 (222 bp)
Type: Others
Protein ID: Protein_1003
Location: 1043033..1043470 (438 bp)
Type: Others
Protein ID: WP_000503169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J3992_RS18480 (J3992_18460)1036905..1037318-414WP_000049420.1VOC family protein-
J3992_RS18485 (J3992_18465)1037502..1038017-516WP_000343779.1GNAT family protein-
J3992_RS18490 (J3992_18470)1038211..1038495+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
J3992_RS18495 (J3992_18475)1038492..1038770+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
J3992_RS18500 (J3992_18480)1038909..1039304-396WP_001000867.1hypothetical protein-
J3992_RS18505 (J3992_18485)1039555..1039680-126WP_001905700.1DUF645 family protein-
J3992_RS18510 (J3992_18490)1039979..1040500-522WP_000921691.1DUF2442 domain-containing protein-
J3992_RS18515 (J3992_18495)1040494..1040763-270WP_001114075.1DUF4160 domain-containing protein-
J3992_RS18520 (J3992_18500)1040830..1040898-69Protein_1000acetyltransferase-
J3992_RS18525 (J3992_18505)1040955..1041554-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
J3992_RS18530 (J3992_18510)1041704..1042576-873WP_000254716.1DUF3800 domain-containing protein-
J3992_RS18535 (J3992_18515)1042751..1042972-222Protein_1003GNAT family N-acetyltransferase-
J3992_RS18540 (J3992_18520)1043033..1043470-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron-hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA1..10441731044172
flankIS/Tn--1043033..1043470437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T206614 WP_000578476.1 NZ_CP077061:1038492-1038770 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T206614 NZ_CP102503:c545-60 [Citrobacter youngae]
GTGGGACGTGTAACAGCACCAGAACCGTTAACAAGCTCCCATCAACTTACTGAGTTCGTCAGTGGCGAGGCTGTACTAGA
TGACTGGCTTAAACAGGGAGGATTAAAAAATCAGGCTCTCGGTTCAGCCCGAACGTTTGTTGTTTGTAAAACAGGCACGA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTAGAAGCAACGGGAAATATCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTCGATTTTTCATTCCGTGGTCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGATAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAGCTTTTATCTTCACCATGGCTTTAAGGCATCGAAAACTCAGGAACGGACATTATTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT206614 WP_000381183.1 NZ_CP077061:1038211-1038495 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT206614 NZ_CP102503:c799-533 [Citrobacter youngae]
ATGAAATCCGATATTCAGCTCAATCTTAGAGCCAAAGAATCGCAAAGAGCACTCATCGATGCTGCTGCAGAGATTCTCCA
TAAATCACGTACAGACTTCATTCTGGAAATGGCATGCCAGGCTGCGGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAGCAGTATGCAGAATTTATCGATATGCTCGATGCACCAGTTTCGGATGATGCTGCCATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References