206603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 8447..9018 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag J3992_RS13605 Protein ID WP_000351248.1
Coordinates 8447..8848 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag J3992_RS13610 Protein ID WP_001080654.1
Coordinates 8848..9018 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS13540 (J3992_13535) 3741..4028 - 288 WP_000426470.1 hypothetical protein -
J3992_RS13545 (J3992_13540) 4180..4848 - 669 WP_000043871.1 hypothetical protein -
J3992_RS13550 (J3992_13545) 4865..4927 - 63 Protein_10 acetyltransferase -
J3992_RS13555 (J3992_13550) 5079..5351 + 273 WP_000246253.1 DUF1778 domain-containing protein -
J3992_RS13560 (J3992_13555) 5348..5845 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
J3992_RS13565 (J3992_13560) 5862..5930 - 69 Protein_13 acetyltransferase -
J3992_RS13570 6047..6151 - 105 WP_228840819.1 DUF645 family protein -
J3992_RS13575 (J3992_13570) 6342..6464 - 123 Protein_15 acetyltransferase -
J3992_RS13580 (J3992_13575) 6521..6976 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
J3992_RS13585 (J3992_13580) 7104..7391 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
J3992_RS13590 (J3992_13585) 7381..7632 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J3992_RS13595 (J3992_13590) 7846..8259 - 414 WP_000049417.1 VOC family protein -
J3992_RS13600 (J3992_13595) 8334..8444 - 111 WP_082798255.1 DUF3265 domain-containing protein -
J3992_RS13605 (J3992_13600) 8447..8848 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
J3992_RS13610 (J3992_13605) 8848..9018 - 171 WP_001080654.1 hypothetical protein Antitoxin
J3992_RS13615 (J3992_13610) 9142..9540 - 399 Protein_23 GNAT family N-acetyltransferase -
J3992_RS13620 (J3992_13615) 9677..9983 - 307 Protein_24 CatB-related O-acetyltransferase -
J3992_RS13625 (J3992_13620) 10051..11031 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
J3992_RS13630 (J3992_13625) 11156..11311 - 156 WP_000751734.1 hypothetical protein -
J3992_RS13635 (J3992_13630) 11479..11913 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
J3992_RS13640 (J3992_13635) 12050..12364 - 315 WP_000071008.1 DNA-binding transcriptional regulator -
J3992_RS13645 (J3992_13640) 12351..12683 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
J3992_RS13650 (J3992_13645) 13024..13251 - 228 WP_001894457.1 DUF1289 domain-containing protein -
J3992_RS13655 (J3992_13650) 13200..13313 - 114 WP_001889158.1 hypothetical protein -
J3992_RS13660 (J3992_13655) 13479..13700 - 222 WP_032468461.1 DUF1289 domain-containing protein -
J3992_RS13665 (J3992_13660) 13709..13823 - 115 Protein_33 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172
flank IS/Tn - - 10051..11031 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T206603 WP_000351248.1 NZ_CP077061:c8848-8447 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T206603 NZ_CP102500:c4585575-4585273 [Citrobacter youngae]
ATGTCTAAATCATTAAATATCAGGAGCTTTCGGGATACATGGCTTGAAGATTTTTTTGAGCGGGCGACATCGCACAGAAA
AATACCAGCGGATATTCATACTGCATTAGCCAGAAAGCTGGATATCATTAATGCGGCTGTTTCGCATCGGGATTTGCGCT
CGCCACCCGGTAACAGATATGAAGAGTTAACCGGAAAATTACAGGAATATTCTTCAATCAGAGTAAACAAGCAGTACCGA
TTAATATTTAAATGGGTTAACGGTAAGGCCGAAGATGTGTACTTAGATCCACACATCTACTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT206603 WP_001080654.1 NZ_CP077061:c9018-8848 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT206603 NZ_CP102500:c4585246-4584905 [Citrobacter youngae]
ATGAAACAGGCAACCAGAAAACCAACGACTGTGGGTGATATCCTGCAATATGAATACCTGGAGCCGCTCGAACTGAAAAT
TAACGATCTGGCTGAAATACTGCATGTTCATCGCAATACGGTGAGCGCACTGGTCAACAATAATCGCAAATTAACAACGG
ATATGGCGTTTCGTTTGGCCAAAGCGTTCGATACCTCCGTTGATTTCTGGCGTAACTTACAGGCGGCGGTTGACCTGTGG
GAAGTTGAAAATGACATGCGGGCGCAAGAAGAACTGAACCGCATTGTTTCGGTTAAAGATTTTATCGCTCAGCGAAATAG
CGAGTCTAAAAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References