204604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 61822..62243 Replicon plasmid pF
Accession NZ_CP076044
Organism Escherichia coli strain Stbl4

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag ITN70_RS21555 Protein ID WP_096937776.1
Coordinates 62118..62243 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 61822..62020 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITN70_RS21530 (57752) 57752..58291 + 540 WP_000290801.1 single-stranded DNA-binding protein -
ITN70_RS21535 (58348) 58348..58581 + 234 WP_000005990.1 DUF905 family protein -
ITN70_RS21540 (58647) 58647..60605 + 1959 WP_000117173.1 ParB/RepB/Spo0J family partition protein -
ITN70_RS21545 (60660) 60660..61094 + 435 WP_010892539.1 conjugation system SOS inhibitor PsiB -
ITN70_RS21550 (61091) 61091..61853 + 763 Protein_54 plasmid SOS inhibition protein A -
- (61822) 61822..62020 + 199 NuclAT_0 - Antitoxin
- (61822) 61822..62020 + 199 NuclAT_0 - Antitoxin
- (61822) 61822..62020 + 199 NuclAT_0 - Antitoxin
- (61822) 61822..62020 + 199 NuclAT_0 - Antitoxin
ITN70_RS21875 (62027) 62027..62176 + 150 Protein_55 DUF5431 family protein -
ITN70_RS21555 (62118) 62118..62243 + 126 WP_096937776.1 type I toxin-antitoxin system Hok family toxin Toxin
ITN70_RS21560 (62544) 62544..62841 - 298 Protein_57 hypothetical protein -
ITN70_RS21570 (63141) 63141..63428 + 288 WP_000107542.1 hypothetical protein -
ITN70_RS21575 (63547) 63547..64368 + 822 WP_001234417.1 DUF932 domain-containing protein -
ITN70_RS21580 (64665) 64665..65267 - 603 WP_000243701.1 transglycosylase SLT domain-containing protein -
ITN70_RS21585 (65588) 65588..65971 + 384 WP_001151527.1 conjugal transfer relaxosome DNA-binding protein TraM -
ITN70_RS21590 (66158) 66158..66847 + 690 WP_000283385.1 conjugal transfer transcriptional regulator TraJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - - 1..98268 98268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(2-37)


Sequences

Toxin        


Download         Length: 42 a.a.        Molecular weight: 4806.72 Da        Isoelectric Point: 8.4890

>T204604 WP_096937776.1 NZ_CP076044:62118-62243 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Download         Length: 126 bp

>T204604 NZ_CP101125:6479582-6479860 [Pseudomonas nunensis]
ATGATCGTTAGCTTTAAGTGTTCTGAGACCGAGTACCTGTTTCGCAACGGTAAGACCCGTATGTGGTCAGCCCTTCTGAA
TGTCGTGGAACGAAAGCTGACGATGCTTGATGCTGCTGCCGTTCTGATGGACCTTCGATCACCGCCGGGCAATCGCTTGG
AGGCGTTGGAGGGGAGTCGAAAAGGTCAGTACAGCATCCGAATCAACGCTCAATGGCGAATTTGCTTTGTATGGGGTCTT
AGCGGGCCAGAGAATGTCGAAATCGTCGATTATCACTGA

Antitoxin


Download         Length: 199 bp

>AT204604 NZ_CP076044:61822-62020 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References