Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 43875..44246 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag JSW75_RS00215 Protein ID WP_001317028.1
Coordinates 44052..44246 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 43875..44053 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS00190 (39830) 39830..41203 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
JSW75_RS00195 (41332) 41332..42267 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
JSW75_RS00200 (42319) 42319..43554 - 1236 WP_000040852.1 site-specific integrase -
JSW75_RS00205 (43556) 43556..43771 - 216 WP_000079604.1 excisionase XisR -
- (43875) 43875..44053 + 179 NuclAT_0 - Antitoxin
- (43875) 43875..44053 + 179 NuclAT_0 - Antitoxin
- (43875) 43875..44053 + 179 NuclAT_0 - Antitoxin
- (43875) 43875..44053 + 179 NuclAT_0 - Antitoxin
JSW75_RS00210 (43850) 43850..44059 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
JSW75_RS00215 (44052) 44052..44246 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
JSW75_RS00220 (44303) 44303..45112 - 810 WP_000166319.1 recombination protein RecT -
JSW75_RS00225 (45105) 45105..47705 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
JSW75_RS00230 (47807) 47807..48082 - 276 WP_000632297.1 protein RacC -
JSW75_RS00235 (48157) 48157..48327 - 171 WP_001352098.1 YdaE family protein -
JSW75_RS00240 (48327) 48327..48548 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 35060..63993 28933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T190289 WP_001317028.1 NZ_CP069386:c44246-44052 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T190289 NZ_CP091231:2859995-2860135 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 179 bp

>AT190289 NZ_CP069386:43875-44053 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References