Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1407809..1408180 Replicon chromosome
Accession NZ_CP069132
Organism Escherichia coli BW25113 substr. CHXR1G20

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag JQK35_RS06910 Protein ID WP_001317028.1
Coordinates 1407986..1408180 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1407809..1407987 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQK35_RS06885 1403764..1405137 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
JQK35_RS06890 1405266..1406201 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
JQK35_RS06895 1406253..1407488 - 1236 WP_000040852.1 site-specific integrase -
JQK35_RS06900 1407490..1407705 - 216 WP_000079604.1 excisionase XisR -
JQK35_RS06905 1407784..1407993 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1407809..1407987 + 179 NuclAT_0 - Antitoxin
- 1407809..1407987 + 179 NuclAT_0 - Antitoxin
- 1407809..1407987 + 179 NuclAT_0 - Antitoxin
- 1407809..1407987 + 179 NuclAT_0 - Antitoxin
JQK35_RS06910 1407986..1408180 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
JQK35_RS06915 1408237..1409046 - 810 WP_000166319.1 recombination protein RecT -
JQK35_RS06920 1409039..1411639 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
JQK35_RS06925 1411741..1412016 - 276 WP_000632297.1 protein RacC -
JQK35_RS06930 1412091..1412261 - 171 WP_001352098.1 conserved protein, Rac prophage -
JQK35_RS06935 1412261..1412482 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1406253..1427927 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T189913 WP_001317028.1 NZ_CP069132:c1408180-1407986 [Escherichia coli BW25113]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T189913 NZ_CP091026:1123917-1124252 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 179 bp

>AT189913 NZ_CP069132:1407809-1407987 [Escherichia coli BW25113]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References