Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-DinJ |
Location | 533218..533703 | Replicon | chromosome |
Accession | NZ_CP067365 | ||
Organism | Lacticaseibacillus rhamnosus strain KF7 |
Toxin (Protein)
Gene name | yafQ | Uniprot ID | C2K0Y1 |
Locus tag | JIO02_RS02520 | Protein ID | WP_005691636.1 |
Coordinates | 533218..533403 (-) | Length | 62 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | A0A508YYT1 |
Locus tag | JIO02_RS02525 | Protein ID | WP_014571130.1 |
Coordinates | 533431..533703 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JIO02_RS02505 | 529406..530014 | - | 609 | WP_005691630.1 | hypothetical protein | - |
JIO02_RS02510 | 530461..531336 | + | 876 | WP_024305787.1 | XRE family transcriptional regulator | - |
JIO02_RS02515 | 531579..532994 | - | 1416 | WP_005691634.1 | DNA polymerase III subunit epsilon | - |
JIO02_RS02520 | 533218..533403 | - | 186 | WP_005691636.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
JIO02_RS02525 | 533431..533703 | - | 273 | WP_014571130.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
JIO02_RS02530 | 534265..534513 | + | 249 | WP_005691639.1 | hypothetical protein | - |
JIO02_RS02535 | 534756..535049 | + | 294 | WP_005684269.1 | metalloregulator ArsR/SmtB family transcription factor | - |
JIO02_RS02540 | 535131..536294 | + | 1164 | WP_005691640.1 | MFS transporter | - |
JIO02_RS02545 | 536448..537023 | + | 576 | WP_014571131.1 | DNA-3-methyladenine glycosylase I | - |
JIO02_RS02550 | 537166..537762 | + | 597 | WP_005691643.1 | IS607 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 528194..539428 | 11234 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6781.86 Da Isoelectric Point: 7.4698
>T186159 WP_005691636.1 NZ_CP067365:c533403-533218 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE
Download Length: 186 bp
>T186159 NZ_CP089236:c161122-160841 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10005.62 Da Isoelectric Point: 9.5939
>AT186159 WP_014571130.1 NZ_CP067365:c533703-533431 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD
Download Length: 273 bp
>AT186159 NZ_CP089236:c161346-161119 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7X2J6C9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A508YYT1 |