Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1407813..1408184 Replicon chromosome
Accession NZ_CP064679
Organism Escherichia coli K-12 strain CETR2G40

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag IVL02_RS06910 Protein ID WP_001317028.1
Coordinates 1407990..1408184 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1407813..1407991 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVL02_RS06885 1403768..1405141 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
IVL02_RS06890 1405270..1406205 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
IVL02_RS06895 1406257..1407492 - 1236 WP_000040852.1 site-specific integrase -
IVL02_RS06900 1407494..1407709 - 216 WP_000079604.1 excisionase XisR -
IVL02_RS06905 1407788..1407997 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1407813..1407991 + 179 NuclAT_0 - Antitoxin
- 1407813..1407991 + 179 NuclAT_0 - Antitoxin
- 1407813..1407991 + 179 NuclAT_0 - Antitoxin
- 1407813..1407991 + 179 NuclAT_0 - Antitoxin
IVL02_RS06910 1407990..1408184 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
IVL02_RS06915 1408241..1409050 - 810 WP_000166319.1 recombination protein RecT -
IVL02_RS06920 1409043..1411643 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
IVL02_RS06925 1411745..1412020 - 276 WP_000632297.1 protein RacC -
IVL02_RS06930 1412095..1412265 - 171 WP_001352098.1 conserved protein, Rac prophage -
IVL02_RS06935 1412265..1412486 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1406257..1427931 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T181464 WP_001317028.1 NZ_CP064679:c1408184-1407990 [Escherichia coli K-12]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T181464 NZ_CP085866:1861256-1861358 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 179 bp

>AT181464 NZ_CP064679:1407813-1407991 [Escherichia coli K-12]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References