Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1409016..1409387 Replicon chromosome
Accession NZ_CP062247
Organism Escherichia coli strain AML002_ev03

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag IHN48_RS06925 Protein ID WP_001317028.1
Coordinates 1409193..1409387 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1409016..1409194 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHN48_RS06900 1404971..1406344 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
IHN48_RS06905 1406473..1407408 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
IHN48_RS06910 1407460..1408695 - 1236 WP_000040852.1 site-specific integrase -
IHN48_RS06915 1408697..1408912 - 216 WP_000079604.1 excisionase XisR -
IHN48_RS06920 1408991..1409200 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1409016..1409194 + 179 NuclAT_0 - Antitoxin
- 1409016..1409194 + 179 NuclAT_0 - Antitoxin
- 1409016..1409194 + 179 NuclAT_0 - Antitoxin
- 1409016..1409194 + 179 NuclAT_0 - Antitoxin
IHN48_RS06925 1409193..1409387 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
IHN48_RS06930 1409444..1410253 - 810 WP_000166319.1 recombination protein RecT -
IHN48_RS06935 1410246..1412846 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
IHN48_RS06940 1412948..1413223 - 276 WP_000632297.1 protein RacC -
IHN48_RS06945 1413298..1413468 - 171 WP_001352098.1 conserved protein, Rac prophage -
IHN48_RS06950 1413468..1413689 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1407460..1429134 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T173984 WP_001317028.1 NZ_CP062247:c1409387-1409193 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T173984 NZ_CP080466:c949659-949258 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 179 bp

>AT173984 NZ_CP062247:1409016-1409194 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References