Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1846592..1846963 Replicon chromosome
Accession NZ_CP058948
Organism Escherichia coli strain SY3626C5

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag HZ988_RS09000 Protein ID WP_001317028.1
Coordinates 1846769..1846963 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1846592..1846770 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ988_RS08975 1842547..1843920 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
HZ988_RS08980 1844049..1844984 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
HZ988_RS08985 1845036..1846271 - 1236 WP_000040852.1 site-specific integrase -
HZ988_RS08990 1846273..1846488 - 216 WP_000079604.1 excisionase XisR -
HZ988_RS08995 1846567..1846776 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1846592..1846770 + 179 NuclAT_0 - Antitoxin
- 1846592..1846770 + 179 NuclAT_0 - Antitoxin
- 1846592..1846770 + 179 NuclAT_0 - Antitoxin
- 1846592..1846770 + 179 NuclAT_0 - Antitoxin
HZ988_RS09000 1846769..1846963 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
HZ988_RS09005 1847020..1847829 - 810 WP_000166319.1 recombination protein RecT -
HZ988_RS09010 1847822..1850422 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
HZ988_RS09015 1850524..1850799 - 276 WP_000632297.1 protein RacC -
HZ988_RS09020 1850874..1851044 - 171 WP_001352098.1 conserved protein, Rac prophage -
HZ988_RS09025 1851044..1851265 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1845036..1866710 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T167997 WP_001317028.1 NZ_CP058948:c1846963-1846769 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T167997 NZ_CP075562:c1440348-1440196 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGACTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 179 bp

>AT167997 NZ_CP058948:1846592-1846770 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References