157971

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 707246..707824 Replicon chromosome
Accession NZ_CP053807
Organism Vibrio cholerae strain SP6G

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag HPY07_RS17020 Protein ID WP_001180243.1
Coordinates 707507..707824 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HPY07_RS17015 Protein ID WP_001961623.1
Coordinates 707246..707488 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY07_RS16975 702297..702734 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
HPY07_RS16980 703084..703560 - 477 WP_001047188.1 GNAT family N-acetyltransferase -
HPY07_RS16985 703791..704063 + 273 WP_000246255.1 DUF1778 domain-containing protein -
HPY07_RS16990 704060..704557 + 498 WP_000982256.1 GNAT family N-acetyltransferase -
HPY07_RS16995 704832..705155 - 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY07_RS17000 705350..705739 - 390 WP_175242351.1 VOC family protein -
HPY07_RS17005 705803..706654 - 852 WP_175242301.1 IS3 family transposase -
HPY07_RS17010 706738..706959 - 222 Protein_728 transposase -
HPY07_RS17015 707246..707488 + 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY07_RS17020 707507..707824 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY07_RS17025 707960..708390 - 431 Protein_731 nucleotidyltransferase family protein -
HPY07_RS17030 708643..709080 - 438 WP_114818872.1 NUDIX pyrophosphatase -
HPY07_RS17035 709078..709155 - 78 Protein_733 GNAT family N-acetyltransferase -
HPY07_RS17040 709279..709389 - 111 Protein_734 DUF645 family protein -
HPY07_RS17045 709811..710059 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY07_RS17050 710049..710339 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY07_RS17055 710388..710948 - 561 WP_114716203.1 GNAT family N-acetyltransferase -
HPY07_RS17060 711274..711435 - 162 WP_175242352.1 hypothetical protein -
HPY07_RS17065 711554..712558 - 1005 WP_000964932.1 LD-carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 702297..702734 437
- inside Genomic island - - 703084..723599 20515
- inside Integron - - 703084..719384 16300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T157971 WP_001180243.1 NZ_CP053807:707507-707824 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T157971 NZ_CP069528:1031716-1031967 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT157971 WP_001961623.1 NZ_CP053807:707246-707488 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Download         Length: 243 bp

>AT157971 NZ_CP069528:1031964-1032218 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure

References