Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 707246..707824 Replicon chromosome
Accession NZ_CP053807
Organism Vibrio cholerae strain SP6G

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag HPY07_RS17020 Protein ID WP_001180243.1
Coordinates 707507..707824 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HPY07_RS17015 Protein ID WP_001961623.1
Coordinates 707246..707488 (+) Length 81 a.a.

Genomic Context

HPY07_RS16985HPY07_RS16990HPY07_RS17015HPY07_RS17020HPY07_RS17045HPY07_RS17050HPY07_RS16975HPY07_RS16980HPY07_RS16995HPY07_RS17000HPY07_RS17005HPY07_RS17010HPY07_RS17025HPY07_RS17030HPY07_RS17035HPY07_RS17040HPY07_RS17055HPY07_RS17060HPY07_RS17065
Location: 703791..704063 (273 bp)
Type: Others
Protein ID: WP_000246255.1
Location: 704060..704557 (498 bp)
Type: Others
Protein ID: WP_000982256.1
Location: 707246..707488 (243 bp)
Type: Antitoxin
Protein ID: WP_001961623.1
Location: 707507..707824 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 709811..710059 (249 bp)
Type: Others
Protein ID: WP_000213183.1
Location: 710049..710339 (291 bp)
Type: Others
Protein ID: WP_000221352.1
Location: 702297..702734 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 703084..703560 (477 bp)
Type: Others
Protein ID: WP_001047188.1
Location: 704832..705155 (324 bp)
Type: Others
Protein ID: WP_080299109.1
Location: 705350..705739 (390 bp)
Type: Others
Protein ID: WP_175242351.1
Location: 705803..706654 (852 bp)
Type: Others
Protein ID: WP_175242301.1
Location: 706738..706959 (222 bp)
Type: Others
Protein ID: Protein_728
Location: 707960..708390 (431 bp)
Type: Others
Protein ID: Protein_731
Location: 708643..709080 (438 bp)
Type: Others
Protein ID: WP_114818872.1
Location: 709078..709155 (78 bp)
Type: Others
Protein ID: Protein_733
Location: 709279..709389 (111 bp)
Type: Others
Protein ID: Protein_734
Location: 710388..710948 (561 bp)
Type: Others
Protein ID: WP_114716203.1
Location: 711274..711435 (162 bp)
Type: Others
Protein ID: WP_175242352.1
Location: 711554..712558 (1005 bp)
Type: Others
Protein ID: WP_000964932.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HPY07_RS16975702297..702734-438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
HPY07_RS16980703084..703560-477WP_001047188.1GNAT family N-acetyltransferase-
HPY07_RS16985703791..704063+273WP_000246255.1DUF1778 domain-containing protein-
HPY07_RS16990704060..704557+498WP_000982256.1GNAT family N-acetyltransferase-
HPY07_RS16995704832..705155-324WP_080299109.1DUF3709 domain-containing protein-
HPY07_RS17000705350..705739-390WP_175242351.1VOC family protein-
HPY07_RS17005705803..706654-852WP_175242301.1IS3 family transposase-
HPY07_RS17010706738..706959-222Protein_728transposase-
HPY07_RS17015707246..707488+243WP_001961623.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
HPY07_RS17020707507..707824+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HPY07_RS17025707960..708390-431Protein_731nucleotidyltransferase family protein-
HPY07_RS17030708643..709080-438WP_114818872.1NUDIX pyrophosphatase-
HPY07_RS17035709078..709155-78Protein_733GNAT family N-acetyltransferase-
HPY07_RS17040709279..709389-111Protein_734DUF645 family protein-
HPY07_RS17045709811..710059+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxin-
HPY07_RS17050710049..710339+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxin-
HPY07_RS17055710388..710948-561WP_114716203.1GNAT family N-acetyltransferase-
HPY07_RS17060711274..711435-162WP_175242352.1hypothetical protein-
HPY07_RS17065711554..712558-1005WP_000964932.1LD-carboxypeptidase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--702297..702734437
-insideGenomic island--703084..72359920515
-insideIntegron--703084..71938416300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T157971 WP_001180243.1 NZ_CP053807:707507-707824 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T157971 NZ_CP069528:1031716-1031967 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT157971 WP_001961623.1 NZ_CP053807:707246-707488 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Download         Length: 243 bp

>AT157971 NZ_CP069528:1031964-1032218 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References