Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 703791..704557 Replicon chromosome
Accession NZ_CP053807
Organism Vibrio cholerae strain SP6G

Toxin (Protein)


Gene name - Uniprot ID A0A233HKB4
Locus tag HPY07_RS16990 Protein ID WP_000982256.1
Coordinates 704060..704557 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0Q0PQR2
Locus tag HPY07_RS16985 Protein ID WP_000246255.1
Coordinates 703791..704063 (+) Length 91 a.a.

Genomic Context

HPY07_RS16970HPY07_RS16985HPY07_RS16990HPY07_RS17015HPY07_RS17020HPY07_RS16960HPY07_RS16965HPY07_RS16975HPY07_RS16980HPY07_RS16995HPY07_RS17000HPY07_RS17005HPY07_RS17010HPY07_RS17025HPY07_RS17030HPY07_RS17035HPY07_RS17040
Location: 701745..702218 (474 bp)
Type: Others
Protein ID: WP_000034756.1
Location: 703791..704063 (273 bp)
Type: Antitoxin
Protein ID: WP_000246255.1
Location: 704060..704557 (498 bp)
Type: Toxin
Protein ID: WP_000982256.1
Location: 707246..707488 (243 bp)
Type: Others
Protein ID: WP_001961623.1
Location: 707507..707824 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 699113..700675 (1563 bp)
Type: Others
Protein ID: WP_001277444.1
Location: 700909..701523 (615 bp)
Type: Others
Protein ID: WP_162808162.1
Location: 702297..702734 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 703084..703560 (477 bp)
Type: Others
Protein ID: WP_001047188.1
Location: 704832..705155 (324 bp)
Type: Others
Protein ID: WP_080299109.1
Location: 705350..705739 (390 bp)
Type: Others
Protein ID: WP_175242351.1
Location: 705803..706654 (852 bp)
Type: Others
Protein ID: WP_175242301.1
Location: 706738..706959 (222 bp)
Type: Others
Protein ID: Protein_728
Location: 707960..708390 (431 bp)
Type: Others
Protein ID: Protein_731
Location: 708643..709080 (438 bp)
Type: Others
Protein ID: WP_114818872.1
Location: 709078..709155 (78 bp)
Type: Others
Protein ID: Protein_733
Location: 709279..709389 (111 bp)
Type: Others
Protein ID: Protein_734
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HPY07_RS16960699113..700675-1563WP_001277444.1methyl-accepting chemotaxis protein-
HPY07_RS16965700909..701523-615WP_162808162.1OmpA family protein-
HPY07_RS16970701745..702218+474WP_000034756.1FKBP-type peptidyl-prolyl cis-trans isomerase-
HPY07_RS16975702297..702734-438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
HPY07_RS16980703084..703560-477WP_001047188.1GNAT family N-acetyltransferase-
HPY07_RS16985703791..704063+273WP_000246255.1DUF1778 domain-containing proteinAntitoxin
HPY07_RS16990704060..704557+498WP_000982256.1GNAT family N-acetyltransferaseToxin
HPY07_RS16995704832..705155-324WP_080299109.1DUF3709 domain-containing protein-
HPY07_RS17000705350..705739-390WP_175242351.1VOC family protein-
HPY07_RS17005705803..706654-852WP_175242301.1IS3 family transposase-
HPY07_RS17010706738..706959-222Protein_728transposase-
HPY07_RS17015707246..707488+243WP_001961623.1type II toxin-antitoxin system Phd/YefM family antitoxin-
HPY07_RS17020707507..707824+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
HPY07_RS17025707960..708390-431Protein_731nucleotidyltransferase family protein-
HPY07_RS17030708643..709080-438WP_114818872.1NUDIX pyrophosphatase-
HPY07_RS17035709078..709155-78Protein_733GNAT family N-acetyltransferase-
HPY07_RS17040709279..709389-111Protein_734DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--702297..702734437
-insideGenomic island--703084..72359920515
-insideIntegron--703084..71938416300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18539.23 Da        Isoelectric Point: 8.7753

>T157970 WP_000982256.1 NZ_CP053807:704060-704557 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T157970 NZ_CP069528:272724-273059 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9713.24 Da        Isoelectric Point: 6.2988

>AT157970 WP_000246255.1 NZ_CP053807:703791-704063 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT157970 NZ_CP069528:272476-272724 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A233HKB4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PQR2

References