Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 703791..704557 Replicon chromosome
Accession NZ_CP053807
Organism Vibrio cholerae strain SP6G

Toxin (Protein)


Gene name - Uniprot ID A0A233HKB4
Locus tag HPY07_RS16990 Protein ID WP_000982256.1
Coordinates 704060..704557 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0Q0PQR2
Locus tag HPY07_RS16985 Protein ID WP_000246255.1
Coordinates 703791..704063 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY07_RS16960 699113..700675 - 1563 WP_001277444.1 methyl-accepting chemotaxis protein -
HPY07_RS16965 700909..701523 - 615 WP_162808162.1 OmpA family protein -
HPY07_RS16970 701745..702218 + 474 WP_000034756.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
HPY07_RS16975 702297..702734 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
HPY07_RS16980 703084..703560 - 477 WP_001047188.1 GNAT family N-acetyltransferase -
HPY07_RS16985 703791..704063 + 273 WP_000246255.1 DUF1778 domain-containing protein Antitoxin
HPY07_RS16990 704060..704557 + 498 WP_000982256.1 GNAT family N-acetyltransferase Toxin
HPY07_RS16995 704832..705155 - 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY07_RS17000 705350..705739 - 390 WP_175242351.1 VOC family protein -
HPY07_RS17005 705803..706654 - 852 WP_175242301.1 IS3 family transposase -
HPY07_RS17010 706738..706959 - 222 Protein_728 transposase -
HPY07_RS17015 707246..707488 + 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY07_RS17020 707507..707824 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY07_RS17025 707960..708390 - 431 Protein_731 nucleotidyltransferase family protein -
HPY07_RS17030 708643..709080 - 438 WP_114818872.1 NUDIX pyrophosphatase -
HPY07_RS17035 709078..709155 - 78 Protein_733 GNAT family N-acetyltransferase -
HPY07_RS17040 709279..709389 - 111 Protein_734 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 702297..702734 437
- inside Genomic island - - 703084..723599 20515
- inside Integron - - 703084..719384 16300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18539.23 Da        Isoelectric Point: 8.7753

>T157970 WP_000982256.1 NZ_CP053807:704060-704557 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T157970 NZ_CP069528:272724-273059 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9713.24 Da        Isoelectric Point: 6.2988

>AT157970 WP_000246255.1 NZ_CP053807:703791-704063 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT157970 NZ_CP069528:272476-272724 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A233HKB4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0PQR2

References