Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1360454..1360825 Replicon chromosome
Accession NZ_CP053607
Organism Escherichia coli strain NEB5-alpha_F'Iq

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag HO392_RS06680 Protein ID WP_001317028.1
Coordinates 1360631..1360825 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1360454..1360632 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO392_RS06655 1356409..1357782 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
HO392_RS06660 1357911..1358846 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
HO392_RS06665 1358898..1360133 - 1236 WP_000040852.1 site-specific integrase -
HO392_RS06670 1360135..1360350 - 216 WP_000079604.1 excisionase XisR -
HO392_RS06675 1360429..1360638 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1360454..1360632 + 179 NuclAT_0 - Antitoxin
- 1360454..1360632 + 179 NuclAT_0 - Antitoxin
- 1360454..1360632 + 179 NuclAT_0 - Antitoxin
- 1360454..1360632 + 179 NuclAT_0 - Antitoxin
HO392_RS06680 1360631..1360825 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
HO392_RS06685 1360882..1361691 - 810 WP_000166319.1 recombination protein RecT -
HO392_RS06690 1361684..1364284 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
HO392_RS06695 1364386..1364661 - 276 WP_000632297.1 protein RacC -
HO392_RS06700 1364736..1364906 - 171 WP_001352098.1 conserved protein, Rac prophage -
HO392_RS06705 1364906..1365127 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1358898..1380572 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T157171 WP_001317028.1 NZ_CP053607:c1360825-1360631 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T157171 NZ_CP069077:c2871368-2870949 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 179 bp

>AT157171 NZ_CP053607:1360454-1360632 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References